In:
Angewandte Chemie International Edition, Wiley, Vol. 54, No. 44 ( 2015-10-26), p. 13002-13006
Abstract:
Heat‐induced radiolabeling (HIR) yielded 89 Zr‐Feraheme (FH) nanoparticles (NPs) that were used to determine NP pharmacokinetics (PK) by positron emission tomography (PET). Standard uptake values indicated a fast hepatic uptake that corresponded to blood clearance, and a second, slow uptake process by lymph nodes and spleen. By cytometry, NPs were internalized by circulating monocytes and monocytes in vitro. Using an IV injection of HIR 89 Zr‐FH (rather than in vitro cell labeling), PET/PK provided a view of monocyte trafficking, a key component of the immune response.
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.201505525
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7
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