In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 157, No. 2 ( 1990-08), p. 208-215
Abstract:
3 H-imipramine binding in 39 drug-free patients with major depression and 44 healthy controls did not differ significantly between the two groups, in male or female subjects or in subgroups of depressed patients divided by endogenicity or dexamethasone suppression test result. 3 H-imipramine binding in depressed patients drug-free for less than three weeks did not differ from those drug-free for longer intervals or from controls. A significant seasonal variation of 3 H-imipramine B max was found, with lower values in summer and autumn. Treatment of depressed patients with imipramine or lofepramine for six weeks increased K D and B max. Methodological modification (in preparation and storage of platelets) does not explain the major differences in results between this study (using frozen platelets), a previous one (using freshly prepared platelets) and others in general, although it might contribute to the range of values reported.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.157.2.208
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
1990
detail.hit.zdb_id:
218103-4
detail.hit.zdb_id:
2021500-9
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