In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 70, No. 24_Supplement ( 2010-12-15), p. S5-5-S5-5
Abstract:
Background: Gene expression profiles in breast cancer mainly reflect ER, PgR, HER2 status, and proliferation. Triple negative breast cancers (TNBC) seem to constitute a heterogenous entity and their relationship to basal-like breast cancers (BLBC) is not fully clear. Further understanding of TNBC is important since new treatments are needed. Materials and Methods: We assembled an Affymetrix dataset of n=579 TNBC (finding cohort n=394, validation cohort n=185). Unsupervised methods identified principal metagenes differing among TNBC in this clean cohort. Clinical data were correlated to these metagenes for the basal-like and apocrine phenotypes, different types of immune cells, the claudin-CD24 signature, markers of blood and adipocytes, as well as signatures for stroma, angiogenesis, and inflammation. Results: 73% of TNBC displayed a basal-like phenotype correlating with poor histological grading and younger age. However, no effect of basal-like phenotype on survival was observed. A good prognosis was obtained for expression of immune cell metagenes and a poor prognosis was associated with metagenes for inflammation, angiogenesis and stromal cells. A combination of high B-cell metagene and low IL-8 metagene expression identified 27% of TNBC with a favourable prognosis (HR 0.25, 95% CI 0.12-0.48; P & lt;0.001) and remained the only significant factor in multivariate analysis with standard parameters. Conclusion: All published prognostic signatures assign TNBC to a poor prognosis group. Use of a subtype-specific dataset not confounded by the main variables of breast cancer allowed the identification of a novel prognostic signature for TNBC. Targeting the IL-8 pathway could be a valuable therapeutic opportunity in TNBC. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr S5-5.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/0008-5472.SABCS10-S5-5
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2010
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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