In:
Expert Reviews in Molecular Medicine, Cambridge University Press (CUP), Vol. 6, No. 17 ( 2004-08-04), p. 1-12
Abstract:
Asthma is a complex disorder in which major genetic and environmental factors interact to initiate the disease and propagate it as a chronic relapsing disorder. Until recently, genetic factors implicated in the disease pathogenesis have been restricted to variants in known molecules involved in the inflammatory or remodelling pathways. This review discusses evidence for a new susceptibility gene for asthma, ADAM33 , which was identified by positional cloning and shown to be selectively expressed in mesenchymal but not immune or inflammatory cells. ADAM33 belongs to a family of membrane–anchored metalloproteinases that also have fusagenic, adhesion and intracellular signalling properties. ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling.
Type of Medium:
Online Resource
ISSN:
1462-3994
DOI:
10.1017/S1462399404007963
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2004
detail.hit.zdb_id:
2035515-4
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