In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 4616-4616
Abstract:
Ulcerative colitis (UC) is a dynamic, idiopathic, chronic inflammatory condition associated with a high colon cancer risk. We have previously shown that American Ginseng (AG) extract prevents and treats colitis. The aim of this study was to better understand the components of American ginseng that suppress colitis. In this study we show that among five different fractions of AG (Butanol, Hexane, Ethylacetate, Dicholoromethane and Water), the Hexane fraction of American ginseng (HAG) has the most effective anti-oxidation and pro-apoptotic effect. This effect of HAG was shown in a mouse macrophage cell line (ANA-1 cells) and in an ex-vivo model (activated primary effector T cells, CD4+/CD25- T cells). Importantly, compared with the entire AG extract, the HAG was more potent in treating colitis in a dextran sulfate sodium (DSS) mouse model. Results from this study move us closer to understanding the molecular components of AG that suppress colitis, and perhaps prevent colon cancer associated with colitis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4616. doi:10.1158/1538-7445.AM2011-4616
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2011-4616
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
Permalink