In:
Journal of Clinical Periodontology, Wiley, Vol. 47, No. 2 ( 2020-02), p. 173-181
Abstract:
Periodontitis has been identified as a moderate but independent risk factor for cardiovascular (CV) disease and progression. The objective of this study (ClinicalTrials.gov Identifier: NCT01045070) was to assess subgingival colonization with selected periodontal pathogens on the occurrence of further adverse CV events in a cohort of CV patients. Methods The prevalence of severe periodontitis including the detection of 11 periodontal pathogens ( Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Treponema denticola, P. intermdia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga ochracea ; HAIN‐Diagnostica ® ) was analysed in 1,002 CV patients The prognostic impact of periodontal pathogens for combined CV endpoint (stroke/TIA, myocardial infarction, CV death, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (HRs) were adjusted for established CV risk factors applying Cox regression. Results In the Kaplan–Meier analysis (log‐rank test: p 〈 .001) and Cox regression (HR: 0.545, 95%‐CI: 0.387–0.773; p = .001), the decreased occurrence of E. corrodens was shown to be an independent predictor for adverse CV events after 3 years of follow‐up. Conclusions The detection of E. corrodens was associated with a reduced risk of adverse CV events in patients with CV disease. The pathophysiological background underlying this association should be investigated in further studies.
Type of Medium:
Online Resource
ISSN:
0303-6979
,
1600-051X
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2026349-1
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