In:
Chemistry & Biodiversity, Wiley, Vol. 21, No. 2 ( 2024-02)
Abstract:
Seven steroidal saponins including three new 16,23‐cyclocholestanes ( 1 ‐ 3 ) and one new pregane ( 4 ) were isolated from the roots of Dracaena cambodiana Pierre ex Gagnep. Their chemical structures were elucidated to be (23 R ,25 R )‐26‐ O ‐ β ‐D‐glucopyranosyl‐16,23‐cyclocholesta‐5,17(20)‐dien‐22‐one‐3 β ,16 α ,26‐triol‐3‐ O ‐ α ‐L‐rhamnopyranosyl‐(1→2)‐[ α ‐L‐rhamnopyranosyl‐(1→3)]‐ β ‐D‐glucopyranoside ( 1 ), (23 R ,25 R )‐26‐ O ‐ β ‐D‐glucopyranosyl‐16,23‐cyclocholesta‐5,17,20(22)‐trien‐3 β ,22,26‐triol‐3‐ O ‐ α ‐L‐rhamnopyranosyl‐(1→3)‐ β ‐D‐glucopyranoside ( 2 ), (23 R ,25 R )‐16,23‐cyclocholesta‐5,16,20(22)‐trien‐3 β ,22,26‐triol‐3‐ O ‐ α ‐L‐rhamnopyranosyl‐(1→3)‐ β ‐D‐glucopyranoside ( 3 ), 3 β ‐[( O ‐ α ‐L‐rhamnopyranosyl‐(1→3)‐[ α ‐L‐rhamnopyranosyl‐(1→2)]‐ β ‐D‐gluco‐pyranosyl)oxy]‐pregna‐5,17(20)‐diene‐16‐one‐20‐carboxylic acid 4′′′′‐ O ‐ β ‐D‐glucopyranosylisopentyl ester ( 4 ), cambodianoside A ( 5 ), diosbulbiside C ( 6 ), and diosbulbiside D ( 7 ), by IR, HR‐ESI‐MS, 1D and 2D NMR spectra. Compounds 1 and 4–7 inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW 264.7 cells with IC 50 values ranging from 19.03±1.84 to 67.92±3.81 μM, whereas compounds 2 and 3 were inactive with IC 50 values over 100 μM.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202301963
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
2136784-X
detail.hit.zdb_id:
2139001-0
SSG:
12
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