In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 173, No. 3 ( 2015-09), p. 333-340
Abstract:
We and others recently reported that in total thyroidectomy (TT), serum triiodothyronine (T 3 ) levels during levothyroxine ( l -T 4 ) therapy were low compared to the preoperative levels, suggesting that the presence of the thyroid tissue affects the balances of serum thyroid hormone levels. However, the effects of remnant thyroid tissue on these balances in thyroidectomized patients have not been established. Methods We retrospectively studied 253 euthyroid patients with papillary thyroid carcinoma who underwent a TT or hemithyroidectomy (HT). We divided the cases into the TT+supplemental l -T 4 (+ l -T 4 ) group ( n =103); the HT+ l -T 4 group ( n =56); and the HT-alone group ( n =94). We compared the postoperative serum levels of free T 4 (FT 4 ) and free T 3 (FT 3 ) and the FT 3 /FT 4 ratio in individual patients with those of controls matched by serum TSH levels. Results The TT+ l -T 4 group had significantly higher FT 4 ( P 〈 0.001), lower FT 3 ( P 〈 0.01) and lower FT 3 /FT 4 ( P 〈 0.001) levels compared to the controls. The HT+ l -T 4 group had FT 4 , FT 3 and FT 3 /FT 4 levels equivalent to those of the controls. The HT-alone group had significantly lower FT 4 ( P 〈 0.01), equivalent FT 3 ( P =0.083), and significantly higher FT 3 /FT 4 ( P 〈 0.001) ratios than the controls. Conclusions The presence of the remnant thyroid tissue was associated with different thyroid hormone balances in thyroidectomized patients, suggesting that T 3 production by remnant thyroid tissue has a substantial effect on the maintenance of postoperative serum T 3 levels.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2015
detail.hit.zdb_id:
1485160-X
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