In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 42, No. 3 ( 2015-09), p. 754-762
Kurzfassung:
To develop and validate a method for quantifying myocardial blood flow (MBF) using dynamic perfusion magnetic resonance imaging (MBF MRI ) at 3.0 Tesla (T) and compare the findings with those of 15 O‐water positron emission tomography (MBF PET ). Methods Twenty healthy male volunteers underwent magnetic resonance imaging (MRI) and 15 O‐water positron emission tomography (PET) at rest and during adenosine triphosphate infusion. The single‐tissue compartment model was used to estimate the inflow rate constant (K1). We estimated the extraction fraction of Gd‐DTPA using K1 and MBF values obtained from 15 O‐water PET for the first 10 subjects. For validation, we calculated MBF MRI values for the remaining 10 subjects and compared them with the MBF PET values . In addition, we compared MBF MRI values of 10 patients with coronary artery disease with those of healthy subjects. Results The mean resting and stress MBF MRI values were 0.76 ± 0.10 and 3.04 ± 0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBF PET values (r = 0.96, P 〈 0.01). The mean stress MBF MRI value was significantly lower for the patients (1.92 ± 0.37) than for the healthy subjects ( P 〈 0.001). Conclusion The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease. J. Magn. Reson. Imaging 2015;42:754–762.
Materialart:
Online-Ressource
ISSN:
1053-1807
,
1522-2586
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
1497154-9
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