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  • Ovid Technologies (Wolters Kluwer Health)  (8)
  • Hirakawa, Yoichiro  (8)
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  • Ovid Technologies (Wolters Kluwer Health)  (8)
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  • 1
    Online Resource
    Online Resource
    Serum Angiopoietin–Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community : The Hisayama Study
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 36, No. 8 ( 2016-08), p. 1686-1691
    Details
    In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 36, No. 8 ( 2016-08), p. 1686-1691
    Abstract: Angiopoietin-like protein 2 (ANGPTL2), a proinflammatory mediator, has been reported to accelerate the development of insulin resistance, endothelial dysfunction, and atherosclerosis in mice. However, no cohort studies have examined the relationship between serum ANGPTL2 levels and the development of cardiovascular disease (CVD) in a general population. Approach and Results— A total of 3005 community-dwelling Japanese aged ≥40 years without a history of CVD were divided into 4 groups according to the quartiles of serum ANGPTL2 concentrations (Q1, lowest and Q4, highest) and followed up for 10 years. The hazards ratios and their 95% confidence intervals for the development of CVD (coronary heart disease or stroke) were estimated using a Cox proportional hazards model. During the follow-up, 219 first-ever CVD events were observed. The risk of CVD increased significantly with elevating ANGPTL2 levels after adjustment for age, sex, serum total cholesterol, use of lipid-lowering agents, ECG abnormalities, smoking habits, alcohol intake, and regular exercise (hazards ratios [95% confidence interval], Q1, 1.00 [reference] ; Q2, 1.27 [0.80–2.04]; Q3, 1.48 [0.95–2.32] ; and Q4, 1.85 [1.20–2.85]; P =0.003 for trend). After additional adjustment for metabolic syndrome components and serum high-sensitivity C-reactive protein levels as an inflammatory marker, the association was attenuated but remained significant (hazards ratios [95% confidence interval], Q1, 1.00 [reference] ; Q2, 1.21 [0.76–1.94]; Q3, 1.38 [0.87–2.17] ; and Q4, 1.66 [1.05–2.60]; P =0.02 for trend). Conclusions— Our findings suggest that elevated serum ANGPTL2 levels are a novel risk factor for the development of CVD in the general population. This association is partially mediated by metabolic disorders and inflammation.
    Type of Medium: Online Resource
    ISSN: 1079-5642 , 1524-4636
    URL: Article
    DOI: 10.1161/ATVBAHA.116.307291
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 1494427-3
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  • 2
    Online Resource
    Online Resource
    NT‐proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of the American Heart Association Vol. 8, No. 17 ( 2019-09-03)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 17 ( 2019-09-03)
    Abstract: Epidemiological evidence implies a link between heart disease and dementia. However, few prospective studies have assessed the association between serum NT ‐pro BNP (N‐terminal pro–B‐type natriuretic peptide) levels and dementia. Methods and Results A total of 1635 community‐dwelling Japanese elderly aged ≥60 years without dementia (57% women, mean age±SD 70.8±7.7 years) were followed up for 10 years. Serum NT ‐pro BNP levels were divided into 4 categories (≤54, 55‐124, 125‐299, and ≥300 pg/mL). The hazard ratios were estimated using a Cox proportional hazards model. During the follow‐up period, 377 subjects developed all‐cause dementia, 247 Alzheimer disease, and 102 vascular dementia. The age‐ and sex‐adjusted incidence of all‐cause dementia was 31.5 per 1000 person‐years and increased significantly with higher serum NT ‐pro BNP levels, being 16.4, 32.0, 35.7, and 45.5, respectively ( P for trend 〈 0.01). Subjects with serum NT ‐pro BNP levels of ≥300 pg/mL had a significantly higher risk of all‐cause dementia (hazard ratio=2.46, 95% CI 1.63‐3.71) than those with serum NT ‐pro BNP levels of ≤54 pg/ mL after adjusting for confounders. Similar risks were observed for Alzheimer disease and vascular dementia. Incorporation of the serum NT ‐pro BNP level into a model with known risk factors for dementia significantly improved the predictive ability for incident dementia (c‐statistics 0.780‐0.787, P =0.02; net reclassification improvement 0.189, P =0.001; integrated discrimination improvement 0.011, P =0.003). Conclusions Higher serum NT ‐pro BNP levels were significantly associated with an increased risk of dementia. Serum NT ‐pro BNP could be a novel biomarker for predicting future risk of dementia in the general elderly population.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.118.011652
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2653953-6
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  • 3
    Online Resource
    Online Resource
    Serum elaidic acid concentration and risk of dementia : The Hisayama Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Neurology Vol. 93, No. 22 ( 2019-11-26), p. e2053-e2064
    Details
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 93, No. 22 ( 2019-11-26), p. e2053-e2064
    Abstract: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Methods In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002–2003 to November 2012 (median 10.3 years, interquartile range 7.2–10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. Results During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia ( p for trend = 0.003) and AD ( p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend 〈 0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. Conclusions The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    URL: Article
    DOI: 10.1212/WNL.0000000000008464
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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  • 4
    Online Resource
    Online Resource
    Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Neurology: Clinical Practice Vol. 8, No. 3 ( 2018-06), p. 223-231
    Details
    In: Neurology: Clinical Practice, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 3 ( 2018-06), p. 223-231
    Abstract: We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2*-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis. Results The crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend 〈 0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ε4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers. Conclusions Our study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.
    Type of Medium: Online Resource
    ISSN: 2163-0402 , 2163-0933
    URL: Article
    DOI: 10.1212/CPJ.0000000000000464
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2645818-4
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  • 5
    Online Resource
    Online Resource
    Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Neurology Vol. 95, No. 5 ( 2020-08-04), p. e508-e518
    Details
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 95, No. 5 ( 2020-08-04), p. e508-e518
    Abstract: To estimate the lifetime cumulative incidence of dementia and its subtypes from a community-dwelling elderly population in Japan. Methods A total of 1,193 community-dwelling Japanese individuals without dementia, aged 60 years or older, were followed up prospectively for 17 years. The cumulative incidence of dementia was estimated based on a death- and dementia-free survival function and the hazard functions of dementia at each year, which were computed by using a Weibull proportional hazards model. The lifetime risk of dementia was defined as the cumulative incidence of dementia at the point in time when the survival probability of the population was estimated to be less than 0.5%. Results During the follow-up, 350 participants experienced some type of dementia; among them, 191 participants developed Alzheimer disease (AD) and 117 developed vascular dementia (VaD). The lifetime risk of dementia was 55% (95% confidence interval, 49%–60%). Women had an approximately 1.5 times greater lifetime risk of dementia than men (65% [57%–72%] vs 41% [33%–49%] ). The lifetime risks of developing AD and VaD were 42% (35%–50%) and 16% (12%–21%) in women vs 20% (7%–34%) and 18% (13%–23%) in men, respectively. Conclusion Lifetime risk of all dementia for Japanese elderly was substantial at approximately 50% or higher. This study suggests that the lifetime burden attributable to dementia in contemporary Japanese communities is immense.
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    URL: Article
    DOI: 10.1212/WNL.0000000000009917
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 6
    Online Resource
    Online Resource
    Association study of susceptibility genes for late-onset Alzheimer’s disease in the Japanese population
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Psychiatric Genetics Vol. 22, No. 6 ( 2012-12), p. 290-293
    Details
    In: Psychiatric Genetics, Ovid Technologies (Wolters Kluwer Health), Vol. 22, No. 6 ( 2012-12), p. 290-293
    Type of Medium: Online Resource
    ISSN: 0955-8829
    URL: Article
    DOI: 10.1097/YPG.0b013e3283586215
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
    detail.hit.zdb_id: 2063156-X
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  • 7
    Online Resource
    Online Resource
    Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly : The Hisayama Study
    Ovid Technologies (Wolters Kluwer Health) ; 2011
    In:  Hypertension Vol. 58, No. 1 ( 2011-07), p. 22-28
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 58, No. 1 ( 2011-07), p. 22-28
    Abstract: The associations between blood pressure and dementia have been inconclusive. We followed up a total of 668 community-dwelling Japanese individuals without dementia, aged 65 to 79 years, for 17 years and examined the associations of late-life and midlife hypertension with the risk of vascular dementia and Alzheimer disease using the Cox proportional hazards model. During the follow-up, 76 subjects experienced vascular dementia and 123 developed Alzheimer disease. The age- and sex-adjusted incidence of vascular dementia significantly increased with elevated late-life blood pressure levels (normal: 2.3, prehypertension: 8.4, stage 1 hypertension: 12.6, and stage 2 hypertension: 18.9 per 1000 person-years; P trend 〈 0.001), whereas no such association was observed for Alzheimer disease ( P trend =0.88). After adjusting for potential confounding factors, subjects with prehypertension and stage 1 or stage 2 hypertension had 3.0-fold, 4.5-fold, and 5.6-fold greater risk of vascular dementia, respectively, compared with subjects with normal blood pressure. Likewise, there was a positive association of midlife blood pressure levels with the risk of vascular dementia but not with the risk of Alzheimer disease. Compared with those without hypertension in both midlife and late life, subjects with midlife hypertension had an ≈5-fold greater risk of vascular dementia, regardless of late-life blood pressure levels. Our findings suggest that midlife hypertension and late-life hypertension are significant risk factors for the late-life onset of vascular dementia but not for that of Alzheimer disease in a general Japanese population. Midlife hypertension is especially strongly associated with a greater risk of vascular dementia, regardless of late-life blood pressure levels.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/HYPERTENSIONAHA.110.163055
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2011
    detail.hit.zdb_id: 2094210-2
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  • 8
    Online Resource
    Online Resource
    Albuminuria Increases the Risks for Both Alzheimer Disease and Vascular Dementia in Community‐Dwelling Japanese Elderly: The Hisayama Study
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Journal of the American Heart Association Vol. 7, No. 2 ( 2018-01-23)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 2 ( 2018-01-23)
    Abstract: Epidemiologic evidence has emerged to reveal an association of albuminuria and low estimated glomerular filtration rate ( eGFR ) with dementia, but the findings are inconsistent. In addition, there are limited studies addressing the association between albuminuria and Alzheimer disease ( AD ). Methods and Results A total of 1562 community‐dwelling Japanese subjects aged ≥60 years without dementia were followed up for 10 years. The outcomes were incidence of all‐cause dementia and its subtypes, namely, AD and vascular dementia (VaD). The hazard ratios for the outcomes were estimated according to urine albumin–creatinine ratio ( UACR ) and eGFR levels using a Cox proportional hazards model. During the follow‐up, 358 subjects developed all‐cause dementia (238 AD and 93 VaD). Higher UACR level was significantly associated with greater multivariable‐adjusted risks of all‐cause dementia (hazard ratios [95% confidence intervals]: 1.00 [reference] , 1.12 [0.78–1.60], 1.65 [1.18–2.30] , and 1.56 [1.11–2.19] for UACR of ≤6.9, 7.0–12.7, 12.8–29.9, and ≥30.0 mg/g, respectively), AD (1.00 [reference], 1.20 [0.77–1.86] , 1.75 [1.16–2.64], and 1.58 [1.03–2.41] , respectively), and VaD (1.00 [reference], 1.03 [0.46–2.29] , 1.94 [0.96–3.95], and 2.19 [1.09–4.38] , respectively). On the other hand, lower eGFR level was marginally associated with greater risk of VaD, but not AD . Subjects with UACR ≥12.8 mg/g and eGFR of 〈 60 mL/min per 1.73 m 2 had 3.3‐fold greater risk of VaD than those with UACR 〈 12.8 mg/g and eGFR of ≥60 mL/min per 1.73 m 2 . Conclusions Albuminuria is a significant risk factor for the development of both AD and VaD in community‐dwelling Japanese elderly. Moreover, albuminuria and low eGFR are mutually associated with a greater risk of VaD.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.117.006693
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2653953-6
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