In:
International Journal of Cancer, Wiley, Vol. 150, No. 5 ( 2022-03), p. 802-815
Abstract:
What's new? Large cell neuroendocrine carcinoma (LCNEC) is a rare malignancy in which about 14 percent of tumors are diagnosed in continuity with lung adenocarcinoma (ADC) or squamous cell carcinoma. Here, to better understand tumorigenesis of LCNEC, e.g. by ADC transformation, the authors analyzed molecular and clinicopathological characteristics of LCNEC‐ADC tumors. Tumors with combined LCNEC‐ and ADC‐parts were found to be clonally related and frequently carried mutations known to occur in pure ADC, with high rates of pRb inactivation linked to neuroendocrine differentiation. By contrast, co‐primary LCNEC and ADC tumors were not often clonally related, suggesting that such tumors should be considered as distinct primary lesions rather than metastatic disease.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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