In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 884-884
Abstract:
Genome-wide association studies of cancer have succeeded in identifying over 100 susceptibility loci, including some, such as those found at chromosome 8q24 and CPTM1L-TERT that influence the risk of several malignancies. As part of the Population Architecture using Genomics and Epidemiology (PAGE) Study, we evaluated whether established risk variants for 19 different cancer sites, excluding the lung, impact the risk of lung cancer. A total of 148 risk variants for these 19 malignancies were selected from genome-wide association studies published through May, 2009. These SNPs were genotyped in a lung cancer case-control study (cases, n=696; controls, n=3,225) nested within the Multiethnic Cohort Study, a large prospective study conducted among African Americans, Latinos, Japanese Americans, Native Hawaiians and whites. Unconditional logistic regression was performed to evaluate the association between SNPs and lung cancer risk, adjusting for age, sex, race/ethnicity, smoking status (current, never, former), and pack-years of cigarette smoking. Eleven of the 148 SNPs were associated with lung cancer risk (P & lt;0.05): two acute lymphocytic leukemia SNPs, two breast cancer SNPs, one glioma/testicular cancer SNP, one neuroblastoma SNP, four prostate cancer SNPs, and one thyroid cancer SNP. By chance, seven associations would be expected for the 148 tests (148 × 0.05=7), suggesting robust significant associations among the 11 associated SNPs. The top associations (P & lt;0.01) were observed with three prostate cancer SNPs (rs10090154 at 8q24-region 1, P=0.0008; rs7837688 at 8q24-region 1, P=0.0009; rs4962416 at CTBP2, P=0.003) and one breast cancer SNP (rs2981578 at FGFR2, P=0.0074). Future analyses will include approximately 4,400 additional lung cancer cases and controls from the Women's Health Initiative (WHI), Arthrosclerosis Risk In Communities (ARIC) study, and the Cardiovascular Health Study (CHS) as part of the PAGE initiative. If these genetic risk factors are replicated, they may clarify shared pathways involved in the carcinogenic process. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 884. doi:10.1158/1538-7445.AM2011-884
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2011-884
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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