In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 3760-3760
Abstract:
Familial clustering has been reported across different cancer sites, suggesting that cancer may be considered a broad phenotype with genetic risk factors that are shared across different malignancies. We, as part of the Population Architecture using Genomics and Epidemiology (PAGE) Study, explored the hypothesis that risk variants established for cancers at any site influence the risk of colorectal cancer. We selected 160 SNPs associated with 20 different cancer sites, including colorectal cancer, from genome-wide association studies published through May, 2009. These SNPs were genotyped in a nested case-control study of 2,077 colorectal cancer cases and 2,685 controls from five racial-ethnic groups (African American, European American, Latino, Japanese American, and Native Hawaiian) within the Multiethnic Cohort. Odds ratios and 95% Confidence Intervals were estimated by unconditional logistic regression to evaluate the association between SNPs and colorectal cancer risk, adjusting for age, sex, and race/ethnicity. We found that 22 risk variants were associated with colorectal cancer risk with P & lt;0.05: one acute lymphocytic leukemia SNP (ALL); one basal cell carcinoma SNP; two breast cancer SNPs; one chronic lymphocytic leukemia (CLL) SNP; four colorectal cancer SNPs (rs6983267, rs4939827, rs16892766, and rs10505477); five lung cancer SNPs; one nasopharyngeal cancer SNP; one neuroblastoma SNP; two pancreatic cancer SNPs; and four prostate cancer SNPs. With more associations than would be expected by chance (8 =160 tests × 0.05), these results suggest robust significant associations. The strongest association (P & lt;0.0001) was for a colorectal cancer risk variant at chromosome 8q24 (rs10505477). Other notable associations (P & lt;0.01) and their originally associated cancer site, excluding known colorectal cancer risk variants (rs6983267, rs4939827, and rs4242382), include rs17483466 (ACOXL) for CLL (P=0.003), rs4242382 (8q24) for prostate cancer (P=0.004), rs10994982 for ALL (P=0.0078), and rs4975616 (TERT-CLPTM1L) for lung cancer (P=0.0079). Future analysis will include approximately 3,600 additional colorectal cancer cases and controls from the Women's Health Initiative (WHI), Arthrosclerosis Risk In Communities Study (ARIC), and the Cardiovascular Health Study (CHS) as part of the PAGE initiative. In conclusion, these results may provide important insights into the biological pathways that are shared across different cancer sites. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3760. doi:10.1158/1538-7445.AM2011-3760
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2011-3760
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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