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  • Wiley  (2)
  • Head, Catherine  (2)
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  • Wiley  (2)
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  • 1
    Online Resource
    Online Resource
    Higher dose dobutamine stress MR imaging in repaired tetralogy of fallot: Observer variance of volumetric assessment compared with normal volunteers
    Wiley ; 2013
    In:  Journal of Magnetic Resonance Imaging Vol. 38, No. 6 ( 2013-12), p. 1356-1361
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    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 38, No. 6 ( 2013-12), p. 1356-1361
    Abstract: To investigate changes in image quality and observer variance between rest and higher‐dose dobutamine stress MR imaging (DS‐MR) in tetralogy of Fallot (TOF) patients and in a group of normal healthy volunteers using both axial and short axis orientation for cardiac volumetric assessment. Materials and Methods Eighteen adult patients (age 34 ± 13) with TOF and severe pulmonary regurgitation and 10 healthy volunteers underwent ventricular MR volumetry at baseline and during dobutamine infusion of 10 μg/kg/min and 20 μg/kg/min. Inter‐observer and intra‐observer agreement was calculated by coefficient of variance (COV). Results Inter‐observer comparison showed good agreement for left ventricle (LV) and right ventricle (RV) end‐diastolic volumes at rest and both stress levels in TOF patients (axial geometry) and in normal volunteers (short axis). During dobutamine stress, the COV in TOF patients increased for LV end‐systolic volume (LV‐ESV) with each level, suggesting less agreement between observers. In contrast, RV‐ESV was much more comparable with a COV 〈 10 at each condition. All volumetric measurements in normal volunteers showed good inter‐observer agreement. Excellent intra‐observer agreement could be seen for all volumetric parameters with COV levels below 7. Conclusion Volumetric assessment during DS‐MR shows excellent inter‐observer agreement, except for LV‐ESV in the TOF patients at higher doses of dobutamine. The axial geometry appears to be reproducible for assessment of RV parameters, and could be considered superior to short axis imaging in patients with repaired TOF. J. Magn. Reson. Imaging 2013;38:1356–1361. © 2013 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v38.6
    DOI: 10.1002/jmri.24103
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1497154-9
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  • 2
    Online Resource
    Online Resource
    Cardiovascular MR dobutamine stress in adult tetralogy of fallot: Disparity between CMR volumetry and flow for cardiovascular function
    Wiley ; 2011
    In:  Journal of Magnetic Resonance Imaging Vol. 33, No. 6 ( 2011-06), p. 1341-1350
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 33, No. 6 ( 2011-06), p. 1341-1350
    Abstract: To evaluate the MR agreement of cardiac function parameters between volumetric (cine SSFP) and phase contrast flow (PC‐flow) assessment in patients with repaired tetralogy of Fallot (r‐TOF) and chronic pulmonary regurgitation (PR) at rest and under dobutamine stress (DS‐MR). Materials and Methods: We studied 18 patients with r‐TOF and severe chronic PR (34 ± 12.7 years, PR fraction [flow] 44 ± 15%) by cardiac MR at rest, 10 and 20 μg/kg/min of dobutamine. We compared analogous functional parameters by volumetry and PC‐flow: (i) Systemic output [left ventricle stroke volume (LV SV ) versus aortic forward flow (AO FF )], (ii) Pulmonary output [right ventricle stroke volume (RV SV ) versus pulmonary forward flow (PA FF )], (iii) PR volume [(RV SV ‐LV SV ) versus pulmonary backward flow (PA BF )], (iv) PR fraction [(RV SV ‐LV SV /RV SV ) versus (PA BF /PA FF )]. Results: We found excellent Bland‐Altman agreement (mean difference ± limits of agreement, mL/beat/m 2 ) at rest for both the systemic (−0.8 ± 5.7) and pulmonary strokes volumes (−0.1 ± 7.6), which slightly deteriorates during DS‐MR. The PR volume showed acceptable agreement at rest (−3.6 ± 15.1), but also further deteriorated during stress (5.4 ± 24). In contrast, the PR fraction showed poor agreement equally at rest (−5.6 ± 22.8) and DS‐MR (3.2 ± 19.2). Conclusion: In r‐TOF with chronic PR, analogous functional parameters should not be used interchangeably between volumetric and PC‐flow assessment during DS‐MR evaluation. J. Magn. Reson. Imaging 2011;33:1341–1350. © 2011 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v33.6
    DOI: 10.1002/jmri.22573
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1497154-9
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