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  • He, Zhiwei  (5)
  • Li, Tong  (5)
  • 1
    Online Resource
    Online Resource
    Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-07-04)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-07-04)
    Abstract: Our previous work reported the association between two single nucleotide polymorphisms (SNPs) in PIN1 promoter and nasopharyngeal carcinoma (NPC) risk with a small sample size in a low incidence area. This study investigated the association between the two SNPs and NPC risk in 733 patients and 895 controls from a high incidence area. The results indicated the genotype and allele frequencies of -842G  〉  C and -667C  〉  T were both significantly different between patients and controls even using the resampling statistics. The -842GC and -667TT genotypes showed a significantly increased risk of NPC (OR = 1.977, 95% CI = 1.339–2.919, P  = 0.001 and OR = 1.438, 95% CI = 1.061–1.922, P  = 0.019, respectively). Compared to the most common -842G-667C haplotype, -842G-667T haplotype and -842C-667C haplotype showed a significantly increased risk of NPC (OR = 1.215, 95% CI = 1.053–1.402, P  = 0.008 and OR = 2.268, 95% CI = 1.530–3.362, P  = 0.001, respectively). Further reporter gene expression suggested that variant -842C-667C and -842G-667T were associated with an enhanced transcriptional activity. In conclusion, our findings suggest that -842G  〉  C and -667C  〉  T in PIN1 promoter are associated with NPC risk; as well as the promoter activity is mediated by functional PIN1 variants.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-017-04156-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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  • 2
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    Online Resource
    Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Translational Medicine Vol. 20, No. 1 ( 2022-12)
    Details
    In: Journal of Translational Medicine, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-12)
    Abstract: Studies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. Our previous study identified Thr184 as a novel phosphorylation site of ATF1. However, the role of phosphorylated ATF1 at Thr184 (p-ATF1-T184) in tumor is unclear. This study figured out the role of p-ATF1-T184 in the metastasis of gastric cancer (GC) and in the regulation of Matrix metallopeptidase 2 (MMP2). Methods Immunohistochemical analysis (IHC) was performed to analyze the level of p-ATF1-T184 and its relationship with clinicopathological characteristics. Wound scratch test, Transwell assay were used to observe the role of p-ATF1-T184 in the invasion and metastasis of GC. The regulation of MMP2 by p-ATF1-T184 was investigated by a series of experiments including quantitative RT-PCR, western blot, gelatin zymography assay, Chromatin immunoprecipitation (ChIP), luciferase reporter assay and cycloheximide experiment. The Cancer Genome Atlas (TCGA) data were used to analyze the expression and prognostic role of ATF1 and MMP2 in GC. Mass spectrometry (MS) following co-immunoprecipitation (co-IP) assay was performed to identify potential upstream kinases that would phosphorylate ATF1 at Thr184. Results High expression level of p-ATF1-T184 was found and significantly associated with lymph node metastasis and poor survival in a GC cohort of 126 patients. P-ATF1-T184 promoted migration and invasion of gastric cancer cells. Phosphorylation of ATF1-T184 could regulate the mRNA, protein expression and extracellular activity of MMP2. P-ATF1-T184 further increased the DNA binding ability, transcription activity, and stabilized the protein expression of ATF1. Moreover, TCGA data and IHC results suggested that the mRNA level of ATF1 and MMP2, and protein level of p-ATF1-T184 and MMP2 could be prognosis markers of GC. Two protein kinase related genes, LRBA and S100A8, were identified to be correlated with the expression ATF1 in GC. Conclusion Our results indicated that p-ATF1-T184 promoted metastasis of GC by regulating MMP2.
    Type of Medium: Online Resource
    ISSN: 1479-5876
    URL: Article
    DOI: 10.1186/s12967-022-03361-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2118570-0
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  • 3
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    Online Resource
    The human ATF 1 rs11169571 polymorphism associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
    Wiley ; 2019
    In:  Cancer Medicine Vol. 8, No. 4 ( 2019-04), p. 1893-1898
    Details
    In: Cancer Medicine, Wiley, Vol. 8, No. 4 ( 2019-04), p. 1893-1898
    Abstract: Our previous work reported activating transcription factor 1 ( ATF 1) is a promotive factor of nasopharyngeal carcinoma ( NPC ) tumorigenesis. This study is to further explore the association between the human ATF 1 rs11169571 polymorphism and the risk of NPC occurrence. The association between ATF 1 rs11169571 and risk of NPC occurrence was investigated in clinical samples of 560 patients and 661 controls obtained from southern China with high incidence of NPC . The genotypes were detected by PCR ‐ RFLP . The differential expression activity of alleles ‐T and ‐C was analyzed with CNE ‐2 and C666‐1 cells by luciferase reporter assay. Our data suggested that the allelic frequency and genotypes were significantly different between patients and controls. Compared to the TT homozygote, the TC and CC genotypes have been shown to be significantly decreased in NPC patients ( OR  = 0.494, 95% CI  = 0.387‐0.629, P   〈  0.001 and OR  = 0.556, 95% CI  = 0.364‐0.851, P  = 0.007, respectively). Compared to the ‐T allele, the ‐C allele is a factor of decreased risk in NPC ( OR  = 0.642, 95% CI  = 0.537‐0.767, P   〈  0.001). Luciferase reporter activity revealed that the ‐T allele confers a higher expression activity than the ‐C allele in CNE 2 cells and C666‐1 cells. In conclusion, ATF 1 rs11169571 which could affect the expression of ATF 1 is associated with NPC risk.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2019.8.issue-4
    DOI: 10.1002/cam4.2022
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2659751-2
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  • 4
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    Online Resource
    miR‑221 inhibits autophagy and targets TP53INP1 in colorectal cancer cells
    Spandidos Publications ; 2017
    In:  Experimental and Therapeutic Medicine ( 2017-11-16)
    Details
    In: Experimental and Therapeutic Medicine, Spandidos Publications, ( 2017-11-16)
    Type of Medium: Online Resource
    ISSN: 1792-0981 , 1792-1015
    URL: Journal
    URL: Article
    DOI: 10.3892/etm
    DOI: 10.3892/etm.2017.5522
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2017
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  • 5
    Online Resource
    Online Resource
    The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression
    Springer Science and Business Media LLC ; 2016
    In:  Cell Death & Disease Vol. 7, No. 12 ( 2016-12-29), p. e2571-e2571
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 7, No. 12 ( 2016-12-29), p. e2571-e2571
    Abstract: The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a series of experiments both in vitro and in vivo were used to characterize a promotive function of ATF1 in NPC tumorigenesis and identify prolyl isomerase Pin1 as a novel regulator of ATF1 at post-transcription. First, we found that overexpression of ATF1 promoted colony formation in NPC. However, the high protein level of ATF1 in NPC was not resulted from high mRNA level. Then, a direct interaction between Pin1 and ATF1 at Thr184 was demonstrated using mammalian two-hybrid assay and coimmunoprecipitation. Cycloheximide (CHX) treatment indicated Pin1 stabilized the expression of ATF1 at post-transcription level. We confirmed that Pin1 upregulated ATF1 transcriptional activity of Bcl-2 using luciferase reporter assay, quantitative RT-PCR and western blot. Furthermore, the newly identified phosphorylation of ATF1 at Thr184 was suggested to have an important role in ATF1 function of transcription and tumor promotion. Finally, high expression of Pin1 in NPC tissue was found to be positively correlated with ATF1. The ATF1 promoted NPC tumorigenesis was regulated by Pin1 both in vitro and in vivo. All these findings clearly state that Pin1 is a novel regulator of ATF1 at Thr184 and thereby enhances ATF1 transcription activity and tumorigenesis promotive function in NPC.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/cddis.2016.349
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2541626-1
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