In:
Molecular Psychiatry, Springer Science and Business Media LLC, Vol. 26, No. 12 ( 2021-12), p. 7211-7224
Abstract:
Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT DRN ) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HT DRN to hypothalamic arcuate nucleus (5-HT DRN → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT 2C and 5-HT 1B receptors, whereas activation of 5-HT DRN to ventral tegmental area (5-HT DRN → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT 2C receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HT DRN neurons via inhibiting their responsiveness to inhibitory GABAergic inputs; non-hunger-driven feeding activates VTA-projecting 5-HT DRN neurons through reducing a potassium outward current. Thus, our results support a model whereby parallel circuits modulate feeding behavior either in response to hunger or to hunger-independent cues.
Type of Medium:
Online Resource
ISSN:
1359-4184
,
1476-5578
DOI:
10.1038/s41380-021-01220-z
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
1502531-7
Permalink