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  • SAGE Publications  (5)
  • He, Rui  (5)
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  • SAGE Publications  (5)
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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Dose-Response Vol. 17, No. 1 ( 2019-01), p. 155932581983214-
    In: Dose-Response, SAGE Publications, Vol. 17, No. 1 ( 2019-01), p. 155932581983214-
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440820-7
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
    In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, SAGE Publications
    Abstract: In this study, we have innovatively proposed a method of in-situ synthesized TiC hard phase to improve the surface mechanical properties of artificial joint materials (Ti6Al4V). In order to explore the optimum graphene oxide (GO) addition, GO/Ti6Al4V composite powders with different proportions (0, 0.5, 1.0, and 1.5 wt.%) were prepared. The homogeneously dispersed GO/Ti6Al4V composite powder was prepared on Ti6Al4V substrate by laser cladding technology. The microstructure, phase composition, and mechanical behavior of GO/Ti6Al4V composite coatings were studied by scanning electron microscope (SEM), optical microscope (OM), energy dispersive spectrometer (EDS), tribometer, hardness tester, and surface profiler. The results showed that the addition of GO could significantly improve the mechanical properties of TC4 substrate. During the preparation of the coating, the grain size of in-situ TiC phase was nanoscale and was distributed between acicular martensite, which played a critical role in enhancing the mechanical properties of the coating. The TiC phase distributed between acicular martensite refine the grain size of [Formula: see text] phase and improve the cutting resistance of the coating. Nevertheless, excessive GO decreased the fluidity of the molten pool, and micro holes tended to generate in the coating, which had a negative impact on the mechanical properties of the coating. At the GO content of 0.5 wt.%, the microhardness of the GO/Ti6Al4V coating was 1.325 times that of pure Ti6Al4V. Under the friction environment of simulated body fluid solution, the average friction coefficient was approximately 0.307 and the wear rate decreased to 3.5 × 10 −7  mm 3 /N · m.
    Type of Medium: Online Resource
    ISSN: 0954-4119 , 2041-3033
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032763-8
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  • 3
    In: HIP International, SAGE Publications, Vol. 21, No. 2 ( 2011-03), p. 146-153
    Abstract: Femoroacetabular impingement (FAI) has been accepted as a potential cause of idiopathic hip pain and osteoarthritis. Few cases of FAI have been reported in the Chinese population. We reviewed radiographic features of patients with idiopathic hip pain to characterize FAI in the Chinese population, any alternative radiographic measures, and potential symptom association. All anteroposterior pelvic radiographs of outpatients (n = 1,128) between December 2007 and August 2008 were reviewed. The radiographic measurements, including anteroposterior alpha angle (AP-α), radial height/radius ratio (R1), and 1/2 radial height/radius ratio (R2) as well as crossover signs, were recorded on both hip joints of all patients. The differences in AP-α, R1, and R2 were compared between cam-type hips (including mixed FAI) and non-cam-type hips (including non-FAI). From the group of patients, 269 were eligible for further evaluation, including those exhibiting FAI at the site of complaint (n = 38) or without symptoms (n = 7). FAI was significantly associated with hip pain (p = 0.009). For painful hips, the frequency of FAI was higher in males than in females (p = 0.038). AP-a was significantly higher in cam-type hips than in non-cam-type hips for either gender (p 〈 0.001, p 〈 0.001). R1 was comparable between the 2 subgroups for either gender (p 〉 0.05, p 〉 0.05), whereas R2 differed significantly (p 〈 0.001, p 〈 0.001). The occurrence of FAI was underestimated in Chinese patients showing negative radiographic findings with idiopathic hip pain. In addition, R2 was used to differentiate cam-type FAI from non-cam-type FAI.
    Type of Medium: Online Resource
    ISSN: 1120-7000 , 1724-6067
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 1475775-8
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  • 4
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 241, No. 18 ( 2016-12), p. 2033-2041
    Abstract: Inflammatory molecules and matrix metalloproteinase (MMPs) have been found over-expressed in the tear film of patients with keratoconus. However, the mechanistic link between inflammatory molecules and MMPs in the pathogenesis of keratoconus remains still elusive. Therefore, we investigated the effect of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) on MMP-1 expression and used IL-6 antibody (IL-6 Ab) to examine the role of IL-6 on TNF-α mediated regulation of MMP-1 in fibroblasts of normal cornea and keratoconus. Real-time polymerase chain reaction, Enzyme-linked immunosorbent assay, and Western blot data demonstrated that MMP-1 and IL-6 were expressed in fibroblasts of normal cornea and keratoconus. Levels of MMP-1 and IL-6 were significantly higher in keratoconus than normal cornea. TNF-α treatment led to a significant increase in IL-6 levels. IL-6 treatment induced MMP-1 synthesis in normal cornea and keratoconus. TNF-α increased MMP-1 expression in a dose- and time-dependent manner and this response was completely inhibited by the IL-6 Ab. In conclusion, these results indicate that fibroblasts of keratoconus shows increased levels of IL-6 and MMP-1 gene and protein expression and IL-6 mediates the TNF-α-induced MMP-1 expression.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 39, No. 1 ( 2024-07), p. 48-57
    Abstract: Electrospinning technology has recently attracted increased attention in the biomedical field, and preparing various cellulose nanofibril membranes for periodontal tissue regeneration has unique advantages. However, the characteristics of using a single material tend to make it challenging to satisfy the requirements for a periodontal barrier film, and the production of composite fibrous membranes frequently impacts the quality of the final fiber membrane due to the influence of miscibility between different materials. In this study, nanofibrous membranes composed of polylactic acid (PLA) and polycaprolactone (PCL) fibers were fabricated using side-by-side electrospinning. Different concentrations of gelatin were added to the fiber membranes to improve their hydrophilic properties. The morphological structure of the different films as well as their composition, wettability and mechanical characteristics were examined. The results show that PCL/PLA dual-fibrous composite membranes with an appropriate amount of gelatin ensures sufficient mechanical strength while obtaining improved hydrophilic properties. The viability of L929 fibroblasts was evaluated using CCK-8 assays, and cell adhesion on the scaffolds was confirmed by scanning electron microscopy and by immunofluorescence assays. The results demonstrated that none of the fibrous membranes were toxic to cells and the addition of gelatin improved cell adhesion to those membranes. Based on our findings, adding 30% gelatin to the membrane may be the most appropriate content for periodontal tissue regeneration, considering the scaffold’s mechanical qualities, hydrophilic properties and biocompatibility. In addition, the PCL-gelatin/PLA-gelatin dual-fibrous membranes prepared using side-by-side electrospinning technology have potential applications for tissue engineering.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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