GLORIA — GEOMAR Library Ocean Research Information Access

Online-Ressource

Genetic evidence of assortative mating in humans

Robinson, Matthew R. ; Kleinman, Aaron ; Graff, Mariaelisa ; [weitere]

Springer Science and Business Media LLC ; 2017

In: Nature Human Behaviour Vol. 1, No. 1 ( 2017-01-09)

zur Merkliste hinzufügen auf der Merkliste

Details

In: Nature Human Behaviour, Springer Science and Business Media LLC, Vol. 1, No. 1 ( 2017-01-09)

Materialart: Online-Ressource

ISSN: 2397-3374

URL: Article

DOI: 10.1038/s41562-016-0016

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2017

ZDB Id: 2885046-4

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

Genetic studies of body mass index yield new insights for obesity biology

Locke, Adam E. ; The LifeLines Cohort Study ; Kahali, Bratati ; [weitere]

Springer Science and Business Media LLC ; 2015

In: Nature Vol. 518, No. 7538 ( 2015-02-12), p. 197-206

zur Merkliste hinzufügen auf der Merkliste

Details

In: Nature, Springer Science and Business Media LLC, Vol. 518, No. 7538 ( 2015-02-12), p. 197-206

Materialart: Online-Ressource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature14177

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2015

ZDB Id: 120714-3

ZDB Id: 1413423-8

SSG: 11

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

A saturated map of common genetic variants associated with human height

Yengo, Loïc ; Vedantam, Sailaja ; Marouli, Eirini ; [weitere]

Springer Science and Business Media LLC ; 2022

In: Nature Vol. 610, No. 7933 ( 2022-10-27), p. 704-712

zur Merkliste hinzufügen auf der Merkliste

Details

In: Nature, Springer Science and Business Media LLC, Vol. 610, No. 7933 ( 2022-10-27), p. 704-712

Kurzfassung: Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes 1 . Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel 2 ) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.

Materialart: Online-Ressource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-022-05275-y

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2022

ZDB Id: 120714-3

ZDB Id: 1413423-8

SSG: 11

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

New genetic loci link adipose and insulin biology to body fat distribution

Shungin, Dmitry ; The ADIPOGen Consortium ; Winkler, Thomas W. ; [weitere]

Springer Science and Business Media LLC ; 2015

In: Nature Vol. 518, No. 7538 ( 2015-02-12), p. 187-196

zur Merkliste hinzufügen auf der Merkliste

Details

In: Nature, Springer Science and Business Media LLC, Vol. 518, No. 7538 ( 2015-02-12), p. 187-196

Materialart: Online-Ressource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature14132

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2015

ZDB Id: 120714-3

ZDB Id: 1413423-8

SSG: 11

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, Thomas W. ; Justice, Anne E. ; Graff, Mariaelisa ; [weitere]

Public Library of Science (PLoS) ; 2016

In: PLOS Genetics Vol. 12, No. 6 ( 2016-6-29), p. e1006166-

zur Merkliste hinzufügen auf der Merkliste

Details

In: PLOS Genetics, Public Library of Science (PLoS), Vol. 12, No. 6 ( 2016-6-29), p. e1006166-

Materialart: Online-Ressource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1006166

DOI: 10.1371/journal.pgen.1006166.s001

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2016

ZDB Id: 2186725-2

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

Defining the role of common variation in the genomic and biological architecture of adult human height

Wood, Andrew R ; The Electronic Medical Records and Genomics (eMERGE) Consortium ; Esko, Tonu ; [weitere]

Springer Science and Business Media LLC ; 2014

In: Nature Genetics Vol. 46, No. 11 ( 2014-11), p. 1173-1186

zur Merkliste hinzufügen auf der Merkliste

Details

In: Nature Genetics, Springer Science and Business Media LLC, Vol. 46, No. 11 ( 2014-11), p. 1173-1186

Materialart: Online-Ressource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3097

RVK:

XA 10000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2014

ZDB Id: 1494946-5

SSG: 12

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, Thomas W. ; Justice, Anne E. ; Graff, Mariaelisa ; [weitere]

Public Library of Science (PLoS) ; 2015

In: PLOS Genetics Vol. 11, No. 10 ( 2015-10-1), p. e1005378-

zur Merkliste hinzufügen auf der Merkliste

Details

In: PLOS Genetics, Public Library of Science (PLoS), Vol. 11, No. 10 ( 2015-10-1), p. e1005378-

Materialart: Online-Ressource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1005378

DOI: 10.1371/journal.pgen.1005378.g001

DOI: 10.1371/journal.pgen.1005378.g002

DOI: 10.1371/journal.pgen.1005378.g003

DOI: 10.1371/journal.pgen.1005378.g004

DOI: 10.1371/journal.pgen.1005378.t001

DOI: 10.1371/journal.pgen.1005378.t002

DOI: 10.1371/journal.pgen.1005378.t003

DOI: 10.1371/journal.pgen.1005378.s001

DOI: 10.1371/journal.pgen.1005378.s002

DOI: 10.1371/journal.pgen.1005378.s003

DOI: 10.1371/journal.pgen.1005378.s004

DOI: 10.1371/journal.pgen.1005378.s005

DOI: 10.1371/journal.pgen.1005378.s006

DOI: 10.1371/journal.pgen.1005378.s007

DOI: 10.1371/journal.pgen.1005378.s008

DOI: 10.1371/journal.pgen.1005378.s009

DOI: 10.1371/journal.pgen.1005378.s010

DOI: 10.1371/journal.pgen.1005378.s011

DOI: 10.1371/journal.pgen.1005378.s012

DOI: 10.1371/journal.pgen.1005378.s013

DOI: 10.1371/journal.pgen.1005378.s014

DOI: 10.1371/journal.pgen.1005378.s015

DOI: 10.1371/journal.pgen.1005378.s016

DOI: 10.1371/journal.pgen.1005378.s017

DOI: 10.1371/journal.pgen.1005378.s018

DOI: 10.1371/journal.pgen.1005378.s019

DOI: 10.1371/journal.pgen.1005378.s020

DOI: 10.1371/journal.pgen.1005378.s021

DOI: 10.1371/journal.pgen.1005378.s022

DOI: 10.1371/journal.pgen.1005378.s023

DOI: 10.1371/journal.pgen.1005378.s024

DOI: 10.1371/journal.pgen.1005378.s025

DOI: 10.1371/journal.pgen.1005378.s026

DOI: 10.1371/journal.pgen.1005378.s027

DOI: 10.1371/journal.pgen.1005378.s028

DOI: 10.1371/journal.pgen.1005378.s029

DOI: 10.1371/journal.pgen.1005378.s030

DOI: 10.1371/journal.pgen.1005378.s031

DOI: 10.1371/journal.pgen.1005378.s032

DOI: 10.1371/journal.pgen.1005378.s033

DOI: 10.1371/journal.pgen.1005378.s034

DOI: 10.1371/journal.pgen.1005378.s035

DOI: 10.1371/journal.pgen.1005378.s036

DOI: 10.1371/journal.pgen.1005378.s037

DOI: 10.1371/journal.pgen.1005378.s038

DOI: 10.1371/journal.pgen.1005378.s039

DOI: 10.1371/journal.pgen.1005378.s040

DOI: 10.1371/journal.pgen.1005378.s041

DOI: 10.1371/journal.pgen.1005378.s042

DOI: 10.1371/journal.pgen.1005378.s043

DOI: 10.1371/journal.pgen.1005378.s044

DOI: 10.1371/journal.pgen.1005378.s045

DOI: 10.1371/journal.pgen.1005378.s046

DOI: 10.1371/journal.pgen.1005378.s047

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2015

ZDB Id: 2186725-2

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, Mariaelisa ; Scott, Robert A. ; Justice, Anne E. ; [weitere]

Public Library of Science (PLoS) ; 2017

In: PLOS Genetics Vol. 13, No. 4 ( 2017-4-27), p. e1006528-

zur Merkliste hinzufügen auf der Merkliste

Details

In: PLOS Genetics, Public Library of Science (PLoS), Vol. 13, No. 4 ( 2017-4-27), p. e1006528-

Materialart: Online-Ressource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1006528

DOI: 10.1371/journal.pgen.1006528.g001

DOI: 10.1371/journal.pgen.1006528.t001

DOI: 10.1371/journal.pgen.1006528.t002

DOI: 10.1371/journal.pgen.1006528.t003

DOI: 10.1371/journal.pgen.1006528.s001

DOI: 10.1371/journal.pgen.1006528.s002

DOI: 10.1371/journal.pgen.1006528.s003

DOI: 10.1371/journal.pgen.1006528.s004

DOI: 10.1371/journal.pgen.1006528.s005

DOI: 10.1371/journal.pgen.1006528.s006

DOI: 10.1371/journal.pgen.1006528.s007

DOI: 10.1371/journal.pgen.1006528.s008

DOI: 10.1371/journal.pgen.1006528.s009

DOI: 10.1371/journal.pgen.1006528.s010

DOI: 10.1371/journal.pgen.1006528.s011

DOI: 10.1371/journal.pgen.1006528.s012

DOI: 10.1371/journal.pgen.1006528.s013

DOI: 10.1371/journal.pgen.1006528.s014

DOI: 10.1371/journal.pgen.1006528.s015

DOI: 10.1371/journal.pgen.1006528.s016

DOI: 10.1371/journal.pgen.1006528.s017

DOI: 10.1371/journal.pgen.1006528.s018

DOI: 10.1371/journal.pgen.1006528.s019

DOI: 10.1371/journal.pgen.1006528.s020

DOI: 10.1371/journal.pgen.1006528.s021

DOI: 10.1371/journal.pgen.1006528.s022

DOI: 10.1371/journal.pgen.1006528.s023

DOI: 10.1371/journal.pgen.1006528.s024

DOI: 10.1371/journal.pgen.1006528.s025

DOI: 10.1371/journal.pgen.1006528.s026

DOI: 10.1371/journal.pgen.1006528.s027

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2017

ZDB Id: 2186725-2

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, Mariaelisa ; Scott, Robert A. ; Justice, Anne E. ; [weitere]

Public Library of Science (PLoS) ; 2017

In: PLOS Genetics Vol. 13, No. 8 ( 2017-8-23), p. e1006972-

zur Merkliste hinzufügen auf der Merkliste

Details

In: PLOS Genetics, Public Library of Science (PLoS), Vol. 13, No. 8 ( 2017-8-23), p. e1006972-

Materialart: Online-Ressource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1006972

DOI: 10.1371/journal.pgen.1006972.s001

DOI: 10.1371/journal.pgen.1006972.s002

DOI: 10.1371/journal.pgen.1006972.s003

DOI: 10.1371/journal.pgen.1006972.s004

DOI: 10.1371/journal.pgen.1006972.s005

DOI: 10.1371/journal.pgen.1006972.s006

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2017

ZDB Id: 2186725-2

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Online-Ressource

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis, Josée ; Langenberg, Claudia ; Prokopenko, Inga ; [weitere]

Springer Science and Business Media LLC ; 2010

In: Nature Genetics Vol. 42, No. 5 ( 2010-5), p. 464-464

zur Merkliste hinzufügen auf der Merkliste

Details

In: Nature Genetics, Springer Science and Business Media LLC, Vol. 42, No. 5 ( 2010-5), p. 464-464

Materialart: Online-Ressource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng0510-464a

RVK:

XA 10000

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2010

ZDB Id: 1494946-5

SSG: 12

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

Online-Ressource

Link zum Verlag

Treffer 1 - 10 | 34 Treffer