In:
Journal of Clinical Periodontology, Wiley, Vol. 41, No. 3 ( 2014-03), p. 232-241
Abstract:
To assess the progression of attachment loss ( AL ) during a 2‐year period according to the presence of JP 2 and non‐ JP 2 genotypes of Aggregatibacter actinomycetemcomitans in a Ghanaian adolescent population. Methods A total of 500 adolescents (mean age 13.2 years, SD ± 1.5) were enrolled in the study. After 2 years, 397 (79.4%) returned for a periodontal re‐examination, including the measurement of AL . The carrier status of the JP 2 and non‐ JP 2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination 2 years earlier. Results Individuals who carried the JP 2 genotype of A. actinomycetemcomitans had a significantly increased risk [relative risk ( RR ) = 7.3] of developing AL ≥ 3 mm. The mean AL at the follow‐up and the mean 2‐year progression of AL were significantly higher in the JP 2 genotype‐positive group ( n = 38) compared with the group positive for the non‐ JP 2 genotypes of A. actinomycetemcomitans ( n = 169), and the group of A. actinomycetemcomitans ‐negative individuals ( n = 190). The JP 2 genotype was strongly associated with the progression of AL ≥ 3 mm ( OR = 14.3). The non‐ JP 2 genotypes of A. actinomycetemcomitans were also, however, less pronounced, associated with the progression of AL ≥ 3 mm ( OR = 3.4). Conclusion The JP 2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL .
Type of Medium:
Online Resource
ISSN:
0303-6979
,
1600-051X
DOI:
10.1111/jcpe.2014.41.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2026349-1
Permalink