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  • Wiley  (33)
  • Hatakeyama, Shingo  (33)
  • 1
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    N ‐glycan signature of serum immunoglobulins as a diagnostic biomarker of urothelial carcinomas
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 4 ( 2021-02), p. 1297-1313
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 4 ( 2021-02), p. 1297-1313
    Abstract: Discriminating between urothelial carcinoma (UC), including bladder cancer (BCa) and upper urinary tract UC (UTUC), is often challenging. Thus, the current study evaluated the diagnostic performance of N ‐glycosylation signatures of immunoglobulins (Igs) for detecting UC, including BCa and UTUC. N ‐glycosylation signatures of Igs from serum samples of the training cohort, including 104 BCa, 68 UTUC, 10 urinary tract infection, and 5 cystitis cases, as well as 62 healthy volunteers, were measured retrospectively using automated capillary‐electrophoresis‐based N ‐glycomics. UTUC or BCa scores were then established through discriminant analysis using N ‐glycan signatures of Igs. Diagnostic performance was evaluated using the area under receiver operating characteristics curve (AUC) and decision curve analyses (DCA). Our result showed that BCa and UTUC scores for discriminating BCa (AUC: 0.977) and UTUC (AUC: 0.867), respectively, provided significantly better clinical performance compared to urine cytology, gross hematuria, or clinical T1 cases. DCA revealed that adding BCa and UTUC scores to gross hematuria status was the best combination for detecting UC and avoiding the need for more intervention without overlooking UC (risk threshold: 13%–93%). The UC nomogram based on the combination of gross hematuria, UTUC score, and BCa score could detect UC with an AUC of 0.891, indicating significantly better performance compared to gross hematuria status in the validation cohort (251 patients). The limitations of this study include its small sample size and retrospective nature. The UC nomogram based on gross hematuria and N ‐glycosylation signatures of Igs can be a promising approach for the diagnosis of UC.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.4
    DOI: 10.1002/cam4.3727
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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  • 2
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    Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut‐off values
    Wiley ; 2018
    In:  International Journal of Urology Vol. 25, No. 9 ( 2018-09), p. 817-824
    Details
    In: International Journal of Urology, Wiley, Vol. 25, No. 9 ( 2018-09), p. 817-824
    Abstract: To compare semen parameters between patients with testicular cancer and other malignancies using various cut‐off values, and to evaluate the correlation between semen parameters and intracytoplasmic sperm injection outcomes. Methods We retrospectively investigated semen parameters before cancer treatment in 117 patients with malignancies who cryopreserved sperm at Hirosaki University Hospital between November 1999 and May 2016. We compared semen parameters between patients with testicular cancer and other malignancies (non‐testicular cancer), seminoma and non‐seminoma, and stage I testicular cancer and stage II/III testicular cancer. The assessment of cut‐off values recommended by the World Health Organization and the total motile sperm count was carried out between the testicular cancer and non‐testicular cancer groups. The intracytoplasmic sperm injection outcomes in those using preserved sperm were assessed. Results Of the 111 patients enrolled, 29 (26%) had testicular cancer and 82 (74%) had non‐testicular cancer. Patients with testicular cancer showed significantly lower total sperm concentration than non‐testicular cancer patients. The cut‐off value of total sperm concentration distinguished the patient proportions exceeding the cut‐off between patients with testicular cancer (41%) and non‐testicular cancer (66%). The comparison between patients with seminoma versus non‐seminoma and stage I versus stage II/III testicular cancer presented no significant differences in semen parameters. No correlation between pretreatment semen parameters and intracytoplasmic sperm injection outcomes was observed. Conclusions Although testicular cancer patients show lower total sperm concentration, intracytoplasmic sperm injection outcomes are acceptable. Further studies on the fertility potential of testicular cancer patients are warranted.
    Type of Medium: Online Resource
    ISSN: 0919-8172 , 1442-2042
    URL: Issue
    URL: Article
    DOI: 10.1111/iju.2018.25.issue-9
    DOI: 10.1111/iju.13732
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2009793-1
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  • 3
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    Geriatric 8 screening of frailty in patients with prostate cancer
    Wiley ; 2020
    In:  International Journal of Urology Vol. 27, No. 8 ( 2020-08), p. 642-648
    Details
    In: International Journal of Urology, Wiley, Vol. 27, No. 8 ( 2020-08), p. 642-648
    Abstract: To evaluate the association between the score of the Geriatric 8 screening tool and treatment by disease stages in patients with prostate cancer. Methods Between January 2017 and June 2019, we prospectively evaluated the Geriatric 8 in 540 prostate cancer patients who were treated with robot‐assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone and standard of care for metastatic hormone‐naïve prostate cancer or castration‐resistant prostate cancer. The primary purpose was the association between frailty (Geriatric 8 ≤14) and robot‐assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone, and metastatic diseases. Secondary purposes included a comparison of the Geriatric 8 scores among the disease status and the influence of Geriatric 8 score on overall survival. Results The median age was 75 years. Geriatric 8 scores ≤14 were seen in 36% of robot‐assisted radical prostatectomy ( n  = 78/214), 57% of radiotherapy ( n  = 119/209), 91% of androgen deprivation therapy alone ( n  = 19/21) and 70% of metastatic diseases ( n  = 67/96). The median Geriatric 8 score in patients treated with robot‐assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone and metastatic diseases was 15.0, 14.0, 12.0 and 12.8, respectively. The median Geriatric 8 score was significantly higher in the metastatic disease than that in localized disease (14.5 vs 12.8, respectively). Robot‐assisted radical prostatectomy patients had a significantly higher Geriatric 8 score than radiotherapy patients, with the cut‐off value of 〈 14.5. The overall survival was significantly different between Geriatric 8 scores ≤13 and 〉 13 in metastatic hormone‐naïve prostate cancer patients, and between Geriatric 8 scores ≤12 and 〉 12 in castration‐resistant prostate cancer patients. Conclusion The Geriatric 8 score is significantly associated with treatment by disease stages in patients with prostate cancer.
    Type of Medium: Online Resource
    ISSN: 0919-8172 , 1442-2042
    URL: Issue
    URL: Article
    DOI: 10.1111/iju.v27.8
    DOI: 10.1111/iju.14256
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2009793-1
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  • 4
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    C‐reactive protein/albumin ratio is a predictive factor for prognosis in patients with metastatic renal cell carcinoma
    Wiley ; 2019
    In:  International Journal of Urology Vol. 26, No. 10 ( 2019-10), p. 992-998
    Details
    In: International Journal of Urology, Wiley, Vol. 26, No. 10 ( 2019-10), p. 992-998
    Abstract: To evaluate the effect of pretreatment C‐reactive protein/albumin ratio and modified Glasgow prognostic score on the prognosis in patients with metastatic renal cell carcinoma. Methods A retrospective study was carried out in 176 patients with metastatic renal cell carcinoma who received first‐line tyrosine kinase inhibitors. The effect of adding inflammatory prognostic scores to the International Metastatic Renal Cell Carcinoma Database Consortium model (International Metastatic Renal Cell Carcinoma Database Consortium‐C‐reactive protein/albumin ratio and International Metastatic Renal Cell Carcinoma Database Consortium‐Glasgow prognostic score models) on overall survival was evaluated using receiver operating characteristic curves. The prognostic value of inflammatory prognostic scores (C‐reactive protein/albumin ratio‐modified Glasgow prognostic score) was tested using the Kaplan–Meier method and Cox proportional regression models. Results Patients were stratified into two groups using the cut‐off value of 0.05: C‐reactive protein/albumin ratio‐low ( 〈 0.05) and C‐reactive protein/albumin ratio‐high (≥0.05). The area under the curve was significantly higher in the International Metastatic Renal Cell Carcinoma Database Consortium‐C‐reactive protein/albumin ratio model (0.720) than that of the International Metastatic Renal Cell Carcinoma Database Consortium model (0.689) and the International Metastatic Renal Cell Carcinoma Database Consortium‐modified Glasgow prognostic score model (0.703). Significant differences were observed in overall survival stratified by the number of risk factors in the International Metastatic Renal Cell Carcinoma Database Consortium‐C‐reactive protein/albumin ratio risk model between one or two and three or four factors ( P  〈   0.001), and three or four and five or more factors ( P  =   0.001). For the patients in the International Metastatic Renal Cell Carcinoma Database Consortium intermediate‐risk group, overall survival was significantly different between the C‐reactive protein/albumin ratio‐low and ‐high groups ( P  =   0.001), whereas it was not significantly different between the patients with one and two International Metastatic Renal Cell Carcinoma Database Consortium risk factors ( P  =   0.106). Conclusion The C‐reactive protein/albumin ratio is a simple and independent predictor of overall survival in patients with metastatic renal cell carcinoma. The predictive activity was significantly improved in the International Metastatic Renal Cell Carcinoma Database Consortium‐C‐reactive protein/albumin ratio model compared with the International Metastatic Renal Cell Carcinoma Database Consortium/International Metastatic Renal Cell Carcinoma Database Consortium‐modified Glasgow prognostic score models.
    Type of Medium: Online Resource
    ISSN: 0919-8172 , 1442-2042
    URL: Issue
    URL: Article
    DOI: 10.1111/iju.v26.10
    DOI: 10.1111/iju.14078
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2009793-1
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  • 5
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    Frailty is significantly associated with the type of urinary diversion in patients with muscle‐invasive bladder cancer
    Wiley ; 2020
    In:  International Journal of Urology Vol. 27, No. 8 ( 2020-08), p. 649-654
    Details
    In: International Journal of Urology, Wiley, Vol. 27, No. 8 ( 2020-08), p. 649-654
    Abstract: To investigate the effect of frailty on the type of urinary diversion after radical cystectomy in patients with muscle‐invasive bladder cancer. Methods Between January 2014 and January 2020, we prospectively evaluated frailty in 88 patients with localized muscle‐invasive bladder cancer, who had received radical cystectomy and urinary diversion. The selection of the type of urinary diversion was determined by the operating surgeon based on performance status, comorbidities, tumor status and the patient’s preference. The frailty evaluation included the Fried phenotype criteria, the modified frailty index and the frailty discriminant score. We investigated the association between frailty and type of urinary diversion, the effect of frailty on postoperative complications and the effect of frailty on overall survival. Results The median age of the selected participants was 68 years. The number of patients with an orthotopic neobladder and any postoperative complications was 54 (61%) and 46 (52%), respectively. Of the frailty assessment tools that were used, Fried phenotype criteria and frailty discriminant score were significantly associated with the selection of non‐orthotopic neobladder urinary diversion. Occurrences of postoperative complications in participants were significantly associated with modified frailty index, but not with Fried phenotype criteria and frailty discriminant score. Multivariate Cox regression analysis showed that a higher frailty discriminant score was significantly associated with poor overall survival, whereas higher Fried phenotype criteria and modified frailty index were not. Conclusion Frailty is significantly associated with the type of urinary diversion, and it should be considered for the selection of urinary diversion in muscle‐invasive bladder cancer patients undergoing radical cystectomy.
    Type of Medium: Online Resource
    ISSN: 0919-8172 , 1442-2042
    URL: Issue
    URL: Article
    DOI: 10.1111/iju.v27.8
    DOI: 10.1111/iju.14263
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2009793-1
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  • 6
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    Trends in the use of neoadjuvant chemotherapy and oncological outcomes for high‐risk upper tract urothelial carcinoma: a multicentre retrospective study
    Wiley ; 2021
    In:  BJU International Vol. 128, No. 4 ( 2021-10), p. 468-476
    Details
    In: BJU International, Wiley, Vol. 128, No. 4 ( 2021-10), p. 468-476
    Abstract: To evaluate temporal trends in neoadjuvant chemotherapy (NAC) utilisation and outcomes in patients with locally advanced upper tract urothelial carcinoma (UTUC). Patients and Methods We included 289 patients from seven hospitals who underwent radical nephroureterectomy (RNU) for locally advanced UTUC (≥cT3 or cN+) between 2000 and 2020. These patients received RNU alone or two to four courses of NAC with either a cisplatin‐ or carboplatin‐based regimen. We evaluated the temporal changes in NAC use and compared the visceral recurrence‐free, cancer‐specific, and overall survival rates. The effect of NAC on oncological outcomes was examined using multivariate Cox regression analysis with inverse probability of treatment weighting (IPTW) models. Results Of 289 patients, 144 underwent NAC followed by RNU (NAC group) and 145 underwent RNU alone (Control [Ctrl] group). NAC use increased significantly from 19% (2006–2010), 58% (2011–2015), to 79% (2016–2020). Pathological downstaging was significantly higher in the NAC group than in the Ctrl group. The IPTW‐adjusted multivariable analyses showed that NAC significantly improved the oncological outcomes in the NAC group compared with the Ctrl group. Moreover, carboplatin‐based NAC significantly improved the oncological outcomes in the NAC group compared with the Ctrl group among patients with chronic kidney disease Stage ≥3. There were no significant differences in oncological outcomes between the cisplatin‐ and carboplatin‐based regimens. Conclusions The use of NAC for high‐risk UTUC increased significantly after 2010. Platinum‐based short‐term NAC followed by immediate RNU may not impede and potentially improves oncological outcomes.
    Type of Medium: Online Resource
    ISSN: 1464-4096 , 1464-410X
    URL: Issue
    URL: Article
    DOI: 10.1111/bju.v128.4
    DOI: 10.1111/bju.15346
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2019983-1
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  • 7
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    Renal metastasis of ovarian granulosa cell tumor
    Wiley ; 2022
    In:  IJU Case Reports Vol. 5, No. 3 ( 2022-05), p. 186-190
    Details
    In: IJU Case Reports, Wiley, Vol. 5, No. 3 ( 2022-05), p. 186-190
    Abstract: We would like to present a rare case of metastatic renal tumor. Case presentation A 60‐year‐old woman presented to our department with a left renal tumor. She underwent a total hysterectomy and right adnexal resection for a stage IA ovarian granulosa cell tumor approximately 15 years ago, followed by left adnexal resection and postoperative chemotherapy with gemcitabine and paclitaxel 6 years ago. She received six courses of gemcitabine and carboplatin to treat a stage IC clear cell adenocarcinoma of the ovary. The patient was diagnosed with the left renal tumor and underwent a laparoscopic left nephrectomy. Immunostaining was positive for α‐inhibin and SF‐1 and showed FOXL2 402C→G (C134W) mutation. Finally, the patient was diagnosed with renal metastasis of a granulosa cell tumor. Conclusion To our knowledge, this is a very rare case of renal metastasis of a granulosa cell tumor with the FOXL2 mutation in an adult.
    Type of Medium: Online Resource
    ISSN: 2577-171X , 2577-171X
    URL: Issue
    URL: Article
    DOI: 10.1002/iju5.v5.3
    DOI: 10.1002/iju5.12433
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2971934-3
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  • 8
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    Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor
    Wiley ; 2009
    In:  International Journal of Cancer Vol. 127, No. 5 ( 2009-12-16), p. 1052-1059
    Details
    In: International Journal of Cancer, Wiley, Vol. 127, No. 5 ( 2009-12-16), p. 1052-1059
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v127:5
    DOI: 10.1002/ijc.25117
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 9
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    STone Episode Prediction: Development and validation of the prediction nomogram for urolithiasis
    Wiley ; 2020
    In:  International Journal of Urology Vol. 27, No. 4 ( 2020-04), p. 344-349
    Details
    In: International Journal of Urology, Wiley, Vol. 27, No. 4 ( 2020-04), p. 344-349
    Abstract: To develop and validate a nomogram predicting the occurrence of a stone episode, given the lack of such predicting risk tools for urolithiasis. Methods We retrospectively analyzed 1305 patients with urolithiasis and 2800 community‐dwelling individuals who underwent a comprehensive health survey. The STone Episode Prediction nomogram was created based on data from the medical records of 600 patients with urolithiasis and 1300 controls, and was validated using a different population of 705 patients with urolithiasis and 1500 controls. Logistic regression analysis was used to construct a model to predict the potential candidate for a stone episode. The predictive ability of the model was evaluated using the results of the area under the receiver operating characteristics curve (area under the curve). Results Age, sex, diabetes mellitus, renal function, serum albumin, and serum uric acid were found to be significantly associated with urolithiasis in the training set and were included in the STone Episode Prediction nomogram. The optimal cut‐off value for the probability of a stone episode using the nomogram was 〉 28% with a sensitivity of 79%, a specificity of 76%, and area under the curve of 0.860. In the validation test, area under the curve for the detection of urolithiasis was 0.815 with a sensitivity of 81% and specificity of 63%. Conclusions Herein, we developed and validated the STone Episode Prediction nomogram that can predict a potential candidate for an episode of urolithiasis. This nomogram might be beneficial for the first step in stone screening in individuals with lifestyle‐related diseases.
    Type of Medium: Online Resource
    ISSN: 0919-8172 , 1442-2042
    URL: Issue
    URL: Article
    DOI: 10.1111/iju.v27.4
    DOI: 10.1111/iju.14203
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2009793-1
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  • 10
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    Prognostic impact of eligibility for adjuvant immunotherapy in locally advanced urothelial cancer
    Wiley ; 2022
    In:  BJUI Compass Vol. 3, No. 2 ( 2022-03), p. 146-153
    Details
    In: BJUI Compass, Wiley, Vol. 3, No. 2 ( 2022-03), p. 146-153
    Abstract: To evaluate the effect of postoperative pathological findings related to the eligibility of adjuvant immunotherapy on oncologic outcomes in patients with localized and locally advanced muscle‐invasive bladder carcinoma (MIBC) and upper tract urothelial carcinoma (UTUC). Patients and methods We retrospectively evaluated 1082 patients treated with radical cystectomy ( n  = 597) and nephroureterectomy ( n  = 485) between January 2000 and April 2021. Patients were divided into two groups: pT3‐4 or pN+ without neoadjuvant chemotherapy and ypT2‐4 or pN+ treated with neoadjuvant chemotherapy (trial‐eligible group) or others (trial‐ineligible group). The primary outcome was the effect of trial eligibility for adjuvant immunotherapy on disease‐free survival (DFS) and overall survival (OS). Secondary outcomes included the additional effect of lymphovascular invasion (LVI) status to the clinical trial criteria on prognosis and a risk model development. Results The median ages of the patients were 69 and 72 years in the MIBC and UTUC groups, respectively. Fifty‐two percent of patients met the trial inclusion criteria. Trial eligibility was significantly associated with poor DFS and OS among patients with MIBC and UTUC. LVI‐positive status was significantly associated with poor prognosis among patients in the trial‐eligible group. A very high risk (LVI+ or pN+ among the pT3‐4 or ypT2‐4) was significantly associated with poor prognosis. Conclusion A total of 52% of patients were eligible for adjuvant immunotherapy. Trial eligibility was significantly associated with a poor prognosis. LVI+ and pN+ may play a key role in candidate selection for adjuvant immunotherapy.
    Type of Medium: Online Resource
    ISSN: 2688-4526 , 2688-4526
    URL: Issue
    URL: Article
    DOI: 10.1002/bco2.v3.2
    DOI: 10.1002/bco2.117
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 3015455-8
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