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  • 1
    In: Journal of Paediatrics and Child Health, Wiley, Vol. 55, No. 2 ( 2019-02), p. 213-215
    Abstract: To demonstrate that unrecognised situation awareness failures events (UNSAFE) transfers are associated with poorer outcomes in the intensive care unit (ICU) at a Japanese children's hospital lacking a rapid response system. Methods This retrospective cohort study was conducted between January 2013 and February 2016. UNSAFE transfers were defined as unplanned in‐hospital ward‐to‐ICU transfers requiring tracheal intubation, vasoactive medications or ≥3 fluid boluses before arrival or in the first 60 min of ICU care. We compared ICU stay duration and mortality between UNSAFE and non‐UNSAFE transfers. Results There were 2126 admissions to the paediatric ICU during the study period, and 244 cases met the definition of an unscheduled in‐hospital transfer (11.5%). Of these, the number of patients transferred following cardiopulmonary resuscitation, in the UNSAFE group and in the non‐UNSAFE group were 9 (3.7%), 68 (28%) and 167 (68%), respectively. In the UNSAFE group, the number of patients who required tracheal intubation, initiation of vasoactive medications or ≥ 3 fluid boluses in the first 60 min of ICU care or before arrival in the ICU was 61 (90%), 38 (56%) and 9 (13%), respectively. ICU stay duration and mortality were significantly poorer in the UNSAFE group than in the non‐UNSAFE group (9 vs. 4 days, P   〈  0.0001; 13 vs. 4.2%, odds ratio = 3.5, 95% confidence interval = 1.2–9.8, P  = 0.020, respectively). Conclusions Patients who experienced UNSAFE transfers had longer ICU stays and higher mortality, and it may be used as a metric of evaluation of effects of rapid response system implementation.
    Type of Medium: Online Resource
    ISSN: 1034-4810 , 1440-1754
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2007577-7
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2022
    In:  Pediatrics International Vol. 64, No. 1 ( 2022-01)
    In: Pediatrics International, Wiley, Vol. 64, No. 1 ( 2022-01)
    Type of Medium: Online Resource
    ISSN: 1328-8067 , 1442-200X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2008621-0
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  • 3
    In: Journal of the Japanese Society of Intensive Care Medicine, Japanese Society of Intensive Care Medicine, Vol. 24, No. 3 ( 2017), p. 332-336
    Type of Medium: Online Resource
    ISSN: 1340-7988 , 1882-966X
    Uniform Title: 経肺圧に基づく換気設定により,体外式膜型人工肺を回避した急性呼吸窮迫症候群の新生児例
    Language: English , Japanese
    Publisher: Japanese Society of Intensive Care Medicine
    Publication Date: 2017
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  • 4
    Online Resource
    Online Resource
    Japanese Society of Intensive Care Medicine ; 2017
    In:  Journal of the Japanese Society of Intensive Care Medicine Vol. 24, No. 1 ( 2017), p. 14-17
    In: Journal of the Japanese Society of Intensive Care Medicine, Japanese Society of Intensive Care Medicine, Vol. 24, No. 1 ( 2017), p. 14-17
    Type of Medium: Online Resource
    ISSN: 1340-7988 , 1882-966X
    Uniform Title: 先天性心疾患術後の抜管後の小児における経鼻高流量酸素療法を利用した一酸化窒素投与の有用性と安全性
    Language: English , Japanese
    Publisher: Japanese Society of Intensive Care Medicine
    Publication Date: 2017
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  • 5
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Pediatric Critical Care Medicine Vol. 21, No. 3 ( 2020-03), p. 302-302
    In: Pediatric Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 21, No. 3 ( 2020-03), p. 302-302
    Type of Medium: Online Resource
    ISSN: 1529-7535
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2070997-3
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2020
    In:  Journal of Intensive Care Vol. 8, No. 1 ( 2020-12)
    In: Journal of Intensive Care, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2020-12)
    Abstract: Influenza virus-associated encephalopathy (IAE) can lead to neurological sequela and mortality among children. Therefore, instant recognition and therapeutic intervention for IAE are crucial. In some clinical subtypes of IAE, steroid pulse therapy might be beneficial, especially when it is administered in the early phase. However, early identification of patients who may benefit from steroid pulse therapy is sometimes difficult. We aimed to assess the effectiveness of early steroid pulse therapy among children with IAE. Methods In this retrospective observational study, we used a national database that covers half of the acute care inpatients across Japan to identify inpatients aged ≤ 18 years with a diagnosis of IAE between July 2010 and March 2017. Unfavorable outcome was defined as a composite outcome of sequela including Japan Coma Scale ≥ 10 at discharge, requiring tracheostomy, mechanical ventilation, enteral tube feeding, rehabilitation at discharge, or in-hospital death. Propensity score matching was performed to compare unfavorable outcome and in-hospital mortality between patients with and without steroid pulse therapy within 2 days of admission. Results Among 692 patients included in the study, the mean age was 5.8 years, and 55.8% were male. The overall in-hospital mortality was 1.3%, and the proportion of the unfavorable outcome was 15.0%. We observed no significant difference in the unfavorable outcome between matched patients (168 patients in each group) with and without early steroid pulse therapy (13.7% vs 8.3%; P  = 0.16) or in-hospital mortality (0.6% vs 1.2%; P  = 1.0). Conclusions We did not observe the effectiveness of early steroid pulse therapy on patient outcomes among children with IAE in our study population including all clinical subtypes of IAE. Further studies considering severity of illness are warranted to determine whether steroid pulse therapy is beneficial, especially for specific clinical subtypes of IAE.
    Type of Medium: Online Resource
    ISSN: 2052-0492
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2739853-5
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  • 7
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Pediatric Critical Care Medicine Vol. 18, No. 9 ( 2017-09), p. 859-862
    In: Pediatric Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 18, No. 9 ( 2017-09), p. 859-862
    Abstract: To investigate whether elevated central venous to arterial C o 2 difference is associated with delayed extubation and prolonged ICU stay in children after cardiac surgery with cardiopulmonary bypass. Design: Retrospective review of medical records. Setting: PICU in a tertiary children’s hospital. Patients: Pediatric patients younger than 18 years old who underwent cardiac surgery with cardiopulmonary bypass between January 2014 and December 2014. Interventions: None. Measurements and Main Results: In total, 114 patients were included in this study. On ICU admission, blood samples were obtained simultaneously from an arterial line and a central venous line. There were no strong correlations between central venous to arterial C o 2 difference (median, 11.1 [8.4–13] mm Hg) and other commonly used variables for the assessment of oxygen delivery including arteriovenous oxyhemoglobin saturation difference ( R 2 = 0.16) and blood lactate concentration ( R 2 = 0.02). When the patients were divided into two groups, based on the C o 2 difference, the high group (difference ≥ 6 mm Hg; n = 103 [90%]) and the low group (difference 〈 6 mm Hg; n = 11 [10%]) showed no difference in the time to extubation (6 vs 5 hr, respectively; p = 0.80) or in the time to discharge from ICU (4 vs 5 d, respectively; p = 0.49). There was no mortality within 30 days of surgery. Conclusions: Elevation of central venous to arterial C o 2 difference on ICU admission in children after cardiac surgery with cardiopulmonary bypass does not appear to be associated with delayed extubation or prolonged ICU stay.
    Type of Medium: Online Resource
    ISSN: 1529-7535
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2070997-3
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2020
    In:  Nursing in Critical Care Vol. 25, No. 3 ( 2020-05), p. 149-155
    In: Nursing in Critical Care, Wiley, Vol. 25, No. 3 ( 2020-05), p. 149-155
    Abstract: Unscheduled readmission to a paediatric intensive care unit can lead to unfavourable patient outcomes. Therefore, determining the incidence and risk factors is important. Previous studies on such readmissions have only focused on the first 48 hours after discharge and described the relative risk factors as unmodifiable. Aim To identify the incidence and risk factors of unscheduled readmission to a paediatric intensive care unit within 7 days of discharge. Design This was a retrospective observational study. Methods Our study population comprised consecutive patients admitted to the paediatric intensive care unit of our tertiary hospital in Japan in 2012 to 2016. We determined the incidence of unscheduled readmission to the unit within 7 days of discharge and identified potential risk factors using multivariable logistic regression analysis. Results Among the 2432 admissions (1472 patients), 60 admissions (2.5%, 44 patients) were followed by ≥1 unscheduled readmission. The median time to readmission was 3.5 days. The most common causes for readmission were respiratory issues and cardiovascular symptoms. The significant risk factors for readmission within 7 days of discharge were unscheduled initial admission (odds ratio [OR]: 3.02; 95% confidence interval [CI:] 1.45‐6.31), admission from a general ward (OR: 5.13; 95% CI: 1.75‐15.0), and withdrawal syndrome during the initial stay (OR: 3.95; 95% CI: 1.53‐10.2). Conclusions The incidence of unscheduled readmission within 7 days was not high (2.5%), and one of the three identified risk factors for readmissions (withdrawal syndrome) is potentially modifiable. Relevance to clinical practice Appropriate treatment of withdrawal syndrome may reduce readmissions and improve patient outcomes. Although unscheduled initial admission and admission from general ward are not modifiable risk factors, careful discharge judgement and follow up after discharge from paediatric intensive care units for high‐risk patients may be beneficial.
    Type of Medium: Online Resource
    ISSN: 1362-1017 , 1478-5153
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2106066-6
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  • 9
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Critical Care Medicine Vol. 47 ( 2019-01), p. 115-
    In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 47 ( 2019-01), p. 115-
    Type of Medium: Online Resource
    ISSN: 0090-3493
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2034247-0
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Pediatrics International Vol. 60, No. 5 ( 2018-05), p. 411-413
    In: Pediatrics International, Wiley, Vol. 60, No. 5 ( 2018-05), p. 411-413
    Abstract: The early detection of clinical deterioration and the prompt escalation of care is important but may be limited in the general ward, especially at night. Identifying variations between work shifts in the number of unscheduled in‐hospital intensive care unit ( ICU ) transfers and emergency transfers involving life‐threatening conditions may help implement targeted interventions to reduce delayed transfers and improve patient safety and outcomes. Methods All unscheduled ICU transfers in a tertiary children's hospital, from January 2013 to December 2016, were reviewed retrospectively. The transfers were categorized into safe transfers and adverse safety events ( ASE ). The 4 year cumulative numbers for each transfer category in each work shift (day, evening, and night) were assessed for comparison. An ASE was defined as transfer after cardiopulmonary resuscitation or tracheal intubation in the ward, or an unrecognized situation awareness failure event transfer, which was defined as previously reported. Results Of 244 unscheduled in‐hospital ICU transfers, 167 were safe transfers and 77 were ASE . The number of unscheduled transfers and of ASE was highest during the day shift ( n = 133 and 40, respectively) and lowest during the night shift ( n = 25 and 12, respectively). In contrast, the proportion of ASE in the unscheduled transfers was higher during the night shift (48%) compared with the day and evening shifts (30% and 31%, respectively). Conclusions The occurrence of unscheduled ICU transfers was disproportionately low during the night shift, whereas the majority of ASE happened during the day shift. Future studies focusing on unravelling the reasons for such variations are warranted.
    Type of Medium: Online Resource
    ISSN: 1328-8067 , 1442-200X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008621-0
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