In:
Twin Research, Cambridge University Press (CUP), Vol. 4, No. 6 ( 2001-12-01), p. 464-477
Abstract:
The classic twin study is sometimes described as “the perfect natural experiment” for the investigation of the aetiology of complex disease, but assumptions of the twin design need to be empirically tested if their results are to be considered unbiased and representative of singleton populations. In this study comparisons of disease and prevalence of lifestyle characteristics have been made between twin participants in the St Thomas' Hospital UK adult twin registry, the largest twin volunteer register in the UK for the study of diseases of ageing, and a parallel population-based study of singleton women. The only differences found were for weight, where monozygotic (MZ) twins were lighter and had a smaller variance than dizygotic (DZ) twins and singletons. For the other variables studied, volunteer twins were not found to differ from age-matched singleton women in distribution or prevalence of: bone mineral density, osteoarthritis, blood pressure, hypertensive drug use, height, history of hysterectomy and ovariectomy, menopausal status and current alcohol and overall tobacco consumption. We conclude that the results of twin studies can be generalised to singleton populations for these measures and disease outcomes.
Type of Medium:
Online Resource
ISSN:
1369-0523
,
2053-6003
DOI:
10.1375/twin.4.6.464
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2001
detail.hit.zdb_id:
2184274-7
detail.hit.zdb_id:
2011013-3
SSG:
12
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