In:
BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-02-20), p. 1-10
Abstract:
The study determined the chemical constituents and anti-inflammatory effects of leaf oil from Cinnamomum subavenium (CS-LO) that has been used in folk medicine to treat various symptoms including inflammation. The anti-inflammatory effects of the oil were evaluated by LPS-stimulated RAW264.7 cells and the Carr-induced hind mouse paw edema model, respectively. In vitro , nitric oxide (NO), prostaglandin E2 (PGE 2 ), TNF- α , IL-6, and IL-1 β were significantly decreased by CS-LO, and the expression of nuclear factor- κ B (NF- κ B) protein was blocked as well. In in vivo, the malondialdehyde (MDA) and paw edema levels were decreased by CS-LO, and the same result came up on the NO and tumor necrosis factor (TNF-a) of serum at the 5th h after Carr injection. In addition, iNOS and COX-2 immunoreactive cells of the paw tissue were decreased significantly by CS-LO (200 mg/kg) in histological examination. The present findings indicated that CS-LO have anti-inflammatory properties, and the effects might be caused through inhibiting iNOS, COX-2, TNF- α , IL-1 β , and IL-6 expression via affecting NF- κ B pathway, which will provide a power scientific basis for CS-LO to be used as the treatment of inflammatory diseases.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2019/1823149
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2019
detail.hit.zdb_id:
2698540-8
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