In:
American Journal of Nephrology, S. Karger AG, Vol. 30, No. 4 ( 2009), p. 383-388
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 This study aimed to investigate the association of the 〈 i 〉 KLOTHO 〈 /i 〉 gene single nucleotide polymorphisms (SNPs), G-395A and C1818T, with various laboratory data in 219 Japanese hemodialysis (HD) patients. 〈 i 〉 Methods: 〈 /i 〉 The genotyping of G-395A in the promoter region and C1818T in exon 4 was performed using polymerase chain reaction with confronting two-pair primers (PCR-CTPP) assay. 〈 i 〉 Results: 〈 /i 〉 In HD patients, the allele frequencies of G-395A were 0.847 for the G allele and 0.153 for the A allele and those of the C1818T were 0.829 for the C allele and 0.171 for the T allele. There were no significant differences in allele frequencies of G-395A and those of the C1818T between HD patients and healthy subjects. Multivariate analysis adjusted for age and duration on HD demonstrated that uric acid was significantly high in A allele carriers of G-395A compared with GG genotype in all and female patients. Low-density lipoprotein cholesterol was significantly low in T allele carriers of C1818T compared with CC genotype in all and male patients. 〈 i 〉 Conclusion: 〈 /i 〉 〈 i 〉 KLOTHO 〈 /i 〉 gene SNPs G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric acid in HD patients.
Type of Medium:
Online Resource
ISSN:
0250-8095
,
1421-9670
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1468523-1
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