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  • Ha, Dao Viet  (4)
  • Mien, Pham Thi  (4)
  • 1
    Online Resource
    Online Resource
    MARINE MICROBES: SOURCES OF NATURAL BIOACTIVE COMPOUNDS FOR APPLICATION IN PHARMACEUTICAL RESEARCH
    Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications) ; 2017
    In:  Vietnam Journal of Marine Science and Technology Vol. 17, No. 2 ( 2017-06-30), p. 169-185
    Details
    In: Vietnam Journal of Marine Science and Technology, Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications), Vol. 17, No. 2 ( 2017-06-30), p. 169-185
    Abstract: Marine microbiology is currently the topic that scientists worldwide are interested in with the aim of searching for bioactive substances. In addition to the inherent microorganisms in marine sediments, other marine lives - associated microorganisms have recently been more invested and important achievements of pharmaceutical research applications have been gained in the last few decades. In this article, we review the milestones in the process of looking for “drugs from the sea” and focus on remarkable results in marine microbes associated with invertebrate and their potential application in drug investigation from the latest published papers in prestigious international journals.
    Type of Medium: Online Resource
    ISSN: 1859-3097
    URL: Article
    DOI: 10.15625/1859-3097/17/2/8365
    Language: Unknown
    Publisher: Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)
    Publication Date: 2017
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  • 2
    Online Resource
    Online Resource
    Bacteria associated with soft coral from Mot island - Nha Trang bay and their antimicrobial activities
    Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications) ; 2020
    In:  Tạp chí Khoa học và Công nghệ biển Vol. 20, No. 2 ( 2020-05-22), p. 209-219
    Details
    In: Tạp chí Khoa học và Công nghệ biển, Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications), Vol. 20, No. 2 ( 2020-05-22), p. 209-219
    Abstract: Microbial communities associated with invertebrates had been considered as a new source of bioactive compounds. The soft coral associated bacteria in Mot island, Nha Trang bay were isolated, extracted and assessed for antagonistic activity against human and coral pathogens, the strongly active strains were identified by 16S rRNA analysis. The soft coral associated bacterium SCN10 had abcd antibacterial pattern which was named for inhibition towards Bacillus subtilis (pattern a), Escherichia coli (pattern b), Salmonella typhimurium (pattern c) and Serratia marcescens (pattern d). It was the nearest strain to the well-known antibiotic producer Bacillus amyloliquefaciens with 99% sequence similarity. Whereas strain SCL19 had abde pattern which means inhibition of the growth of B. subtilis, E. coli, S. marcescens and Vibrio parahaemolyticus (pattern e). This strain SCL19 affiliated with Bacillus sp. strain A-3-23B with 99.8% identity. In addition to antimicrobial activity to the aforementioned tested bacteria, the isolate SCX15 also inhibited Vibrio alginolyticus (pattern f) and Candida albicans (pattern g), so this isolate possessed abcdefg antimicrobial pattern. The coral associated isolate SCX15 was identified as Bacillus velezensis with 99% sequence similarity. Among the 78 screened strains, 25 isolates possessed antibacterial activity against at least one of seven tested microorganisms and exhibited 12 different types of antimicrobial activities, suggesting that they can produce many different natural substances with antibacterial activity.
    Type of Medium: Online Resource
    ISSN: 1859-3097
    URL: Article
    DOI: 10.15625/1859-3097/20/2/15089
    Language: Unknown
    Publisher: Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)
    Publication Date: 2020
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  • 3
    Online Resource
    Online Resource
    Antimicrobial Activities of Sponge-Derived Microorganisms from Coastal Waters of Central Vietnam
    MDPI AG ; 2020
    In:  Journal of Marine Science and Engineering Vol. 8, No. 8 ( 2020-08-08), p. 594-
    Details
    In: Journal of Marine Science and Engineering, MDPI AG, Vol. 8, No. 8 ( 2020-08-08), p. 594-
    Abstract: Bacteria associated with invertebrates are considered as good sources for biologically active compounds. Sponge-derived bacteria were screened for antimicrobial activities, the presence of the cluster genes of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs), and through a colony picking method. Crude extracts of broth cultures were tested for microbial inhibition. Eleven out of 25 isolated strains showed inhibition of at least one of eight tested indicator microorganisms. Antimicrobial activities were observed in the strains coded HM5, HM6, and HM9 with the presence of NRPS and PKSII genes, whereas the isolate HM21 held both NRPS and PKSII and inhibited only the growth of Bacillus subtilis by the well diffusion method and only inhibited Serratia marcescens by the colony picking method. Two isolates, HM5 and HM6, belonged to the species of Bacillus. Interestingly, the isolate HM9 was nearest to Streptomyces mexicanusT NBRC100915 (GenBank accession number AB249966) with 94% sequence similarity. This potent strain HM9 could possibly be considered as a new species and a good source for bioactive compound discovery. Some isolates showed NRPS/PKS genes but did not exhibit antimicrobial activity. Thus, we suggested that both molecular and traditional methods should be conducted for the screening of antimicrobial producers.
    Type of Medium: Online Resource
    ISSN: 2077-1312
    URL: Article
    DOI: 10.3390/jmse8080594
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2738390-8
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  • 4
    Online Resource
    Online Resource
    KHẢ NĂNG KHÁNG KHÁNG SINH CỦA VI KHUẨN BIỂN TẠI HÒN MỘT VỊNH NHA TRANG
    Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications) ; 2018
    In:  Tạp chí Khoa học và Công nghệ Biển Vol. 17, No. 4 ( 2018-08-06), p. 480-489
    Details
    In: Tạp chí Khoa học và Công nghệ Biển, Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications), Vol. 17, No. 4 ( 2018-08-06), p. 480-489
    Abstract: Drug resistance is now an issue of deep scientific concern all over the world as more antibiotic resistant bacteria have been detected in many regions and countries in recent years. Using of antibiotics for aquaculture is quite common in developing countries including Vietnam. This causes the spread of antibiotic resistant bacteria in the environment. Testing of antibiotic resistant bacteria was carried out in commercial marine aquaculture and tourist zones in Hon Mot in the Nha Trang bay with five different antibiotics namely chloramphenicol, tetracycline, cefazolin, streptomycin, and gentamicin on Mueller Hinton Agar. A total of 18 strains composed of 14 Gram positive strains, 4 Gram negative strains were tested for antibiotic resistance. Strain KH1 showed the least sensitive to tetracycline with average radius of 4.0 mm, while strain T1 showed the least sensitive to streptomycin with average radius of 4.2 mm. The strains KH6 and T7 showed resistance to cefazolin with radius of inhibition zone of 0 mm and 2 mm, respectively. The strain KH6 was confirmed as Bacillus sp. Antibiotic resistant bacteria were now found in Nha Trang bay, so there may be additional resistant bacteria, even multi-antibiotic resistant bacteria outside the marine environment. This is a matter for further research that should provide solutions to limit the rise of antibiotic resistant bacteria.
    Type of Medium: Online Resource
    ISSN: 1859-3097 , 1859-3097
    URL: Article
    DOI: 10.15625/1859-3097/17/4/8672
    Language: Unknown
    Publisher: Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)
    Publication Date: 2018
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