In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2014, No. 33 ( 2014-11), p. 5741-5751
Abstract:
Four novel complexes based on the ligand piperazine (Pip) in a chair conformation have been synthesized, namely [Pd(5,5′‐dcbpy)Pip] · 4H 2 O ( 1 ), [Pt(5,5′‐dcbpy)Pip] · 3H 2 O ( 2 ), [Pd(4,4′‐dcbpy)Pip] · 4H 2 O ( 3 ), and [Pt(4,4′‐dcbpy)Pip] · 2H 2 O ( 4 ; 4,4′‐dcbpy = 2,2′‐bipyridyl‐4,4′‐dicarboxylate, 5,5′‐dcbpy = 2,2′‐bipyridyl‐5,5′‐dicarboxylate). The four complexes were characterized by elemental analysis, FTIR spectroscopy, 1 H and 13 C NMR spectroscopy, and single‐crystal X‐ray diffraction analysis. In addition, gel electrophoresis was performed on the four complexes and further insight into these complexes was gained by quantum chemistry calculations. The interaction of these complexes with fish sperm DNA (FS‐DNA) was studied by UV/Vis and fluorescence spectroscopy, which revealed that they have the ability to bind to FS‐DNA. The IC 50 values of the four complexes range from 8.3 to 32.5 μ M . Finally, we studied the cytotoxic activities of complexes 1 – 4 against two different cancer cell lines.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2014.33
DOI:
10.1002/ejic.201402532
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1475009-0
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