In:
Cancer Science, Wiley, Vol. 109, No. 6 ( 2018-06), p. 1909-1919
Abstract:
Little is known about the value of the nutritional risk screening 2002 ( NRS 2002) scale in nasopharyngeal carcinoma ( NPC ). We conducted a large‐scale study to address this issue. We employed a big‐data intelligence database platform at our center and identified 3232 eligible patients treated between 2009 and 2013. Of the 3232 (12.9% of 24 986) eligible patients, 469 (14.5%), 13 (0.4%), 953 (29.5%), 1762 (54.5%) and 35 (1.1%) had NRS 2002 scores of 1, 2, 3, 4 and 5, respectively. Survival outcomes were comparable between patients with NRS 2002 〈 3 and ≥3 (original scale). However, patients with NRS 2002 ≤3 vs 〉 3 (regrouping scale) had significantly different 5‐year disease‐free survival ( DFS ; 82.7% vs 75.0%, P 〈 .001), overall survival ( OS ; 88.8% vs 84.1%, P = .001), distant metastasis‐free survival ( DMFS ; 90.2% vs 85.9%, P = .001) and locoregional relapse‐free survival ( LRRFS ; 91.6% vs 87.2%, P = .001). Therefore, we proposed a revised NRS 2002 scale, and found that it provides a better risk stratification than the original or regrouping scales for predicting DFS (area under the curve [ AUC ] = 0.530 vs 0.554 vs 0.577; P 〈 .05), OS ( AUC = 0.534 vs 0.563 vs 0.582; P 〈 .05), DMFS ( AUC = 0.531 vs 0.567 vs 0.590; P 〈 .05) and LRRFS ( AUC = 0.529 vs 0.542 vs 0.564; P 〈 .05 except scale A vs B). Our proposed NRS 2002 scale represents a simple, clinically useful tool for nutritional risk screening in NPC .
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2018.109.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
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