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  • Hindawi Limited  (7)
  • Guo, Ying  (7)
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Verlag/Herausgeber
  • Hindawi Limited  (7)
Person/Organisation
Sprache
Erscheinungszeitraum
Fachgebiete(RVK)
  • 1
    Online-Ressource
    Online-Ressource
    Effects of Microvesicles on Cell Apoptosis under Hypoxia
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-04-17), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-04-17), p. 1-11
    Kurzfassung: Hypoxia, as one of the severe cellular stresses, can cause cellular injury and even cell death. Apoptosis is the main mechanism of regulating cell death and is closely related to the cell death caused by hypoxia. However, hypoxia-induced apoptosis is not entirely the result of direct hypoxic stimulus of cells. In recent years, it has been found that cells injured by hypoxia can shed a kind of membranous vesicles, which are called microvesicles (MVs). MVs can carry bioactive molecules from injured mother cells and appear in blood, cerebrospinal fluid, and other body fluids. MVs can induce normal cell apoptosis by transferring bioactive molecules into adjacent cells and amplifying the hypoxic injury in an organism. This review summarizes the characteristic changes of MVs derived from hypoxic cells and the mechanism of normal cell apoptosis mediated by hypoxic cell-derived MVs. Finally, we introduce the significance of this apoptosis-apoptosis cascade reaction in hypoxic diseases.
    Materialart: Online-Ressource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/5972152
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2455981-7
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Acupoint Injection for Nonspecific Chronic Low Back Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-10-28), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-10-28), p. 1-12
    Kurzfassung: Introduction. Nonspecific chronic low back pain (NCLBP) became a public health and economic problem. Acupoint injection was used widely for patients with NCLBP. However, there were inconsistent results on the efficacy for these people. Therefore, this review was performed to systematically assess the efficacy and safety of acupoint injection. Materials and Methods. The literature sources were collected via EMBASE, Medline, CENTRAL, CINAHL, CNKI, VIP, Wanfang, and Sino-Med Database from their inception to October 13, 2019. Endnote X7, widely used document management software, was used to manage and screen the literature sources. Each record was screened according to the predetermined inclusion criteria by two review authors independently. Quality assessment tool, “Risk of table,” was used to assess the quality of the included studies according to the recommendation of the Cochrane Handbook for Systematic Reviews of Interventions. Data extraction was performed by one reviewer and verified by another reviewer. Any disagreement was addressed via consulting with a third reviewer in the abovementioned processes. All procedures were performed according to the Cochrane Handbook for Systematic Reviews of Interventions. Results. This review included 13 studies involving 1381 patients with NCLBP. Quantitative analysis results indicated that there is no sufficient evidence that acupoint injection can improve the pain of patients with low back pain based on two trails: Visual Analogue Scale (VAS: MD = −1.33, 95% confidence interval (95% CI) −3.30 to 0.64, P = 0.18 , random-effect model). When assessing the effectiveness of acupoint injection therapy, the results indicated that acupoint injection can improve the effective rate for nonspecific chronic low back pain (OR = 3.64, 95% CI 2.4 to 5.21, P 〈 0.0001 , fixed-effect model). Conclusion. There is insufficient evidence to indicate that acupoint injection therapy could improve the pain for patients with NCLBP. However, the level of evidence was downgraded to “very low quality” because of the poor methodological quality and clinical heterogeneity. The results should be interpreted with caution. Higher quality RCTs with more appropriate comparison, more objective outcome instruments, and adequate follow-up periods are necessary to assess the efficacy of acupoint injection for NCLBP. The PROSPERO Research registration identifying number is CRD42019119158.
    Materialart: Online-Ressource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2020/3976068
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    SWATH HM -Based Metabolomics of Follicular Fluid in Patients Shows That Progesterone Adversely Affects Oocyte Quality
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018), p. 1-8
    Kurzfassung: Objective . We reveal the relationship between progesterone level in follicular fluid and oocyte quality based on sequential window acquisition of all theoretical fragment-ion spectra (SWATH™), a powerful high-resolution mass spectrometric data independent acquisition technique. Method . Follicular fluid samples were collected from 22 subjects (the level of progesterone 〉 1.5 ng/mL) of progesterone group, as well as from 22 subjects (the level of progesterone 〈 1.5 ng/mL) of control group, and analyzed using UPLC-Q-TOF. All methods were performed in accordance with ISO 9001:2008. Novel SWATH acquisition mode on an ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (with resolving power 20,000–40,000) was investigated for the analysis of human follicular fluid. The principal component variable grouping detects intersample variable correlation and groups variables with similar profiles which simplifies interpretation and highlights related ions and fragments. It can also extract product ion spectra from the data collected by fragmenting a wide precursor ion window. Results . Follicular fluid from the two groups differed with respect to five metabolites. Follicular fluid from the progesterone group contained elevated levels of 8-hydroxyguanosine and 4-hydroxynonenal and reduced levels of ATP, estradiol, and L-carnitine. The increased progesterone level on the day of HCG injection could negatively impact oocyte quality, thus reducing the pregnancy rate of IVF patients.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/1780391
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Multimode Pedestrian Dead Reckoning Gait Detection Algorithm Based on Identification of Pedestrian Phone Carrying Position
    Hindawi Limited ; 2019
    In:  Mobile Information Systems Vol. 2019 ( 2019-10-31), p. 1-14
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2019 ( 2019-10-31), p. 1-14
    Kurzfassung: Pedestrian dead reckoning (PDR) is an essential technology for positioning and navigation in complex indoor environments. In the process of PDR positioning and navigation using mobile phones, gait information acquired by inertial sensors under various carrying positions differs from noise contained in the heading information, resulting in excessive gait detection deviation and greatly reducing the positioning accuracy of PDR. Using data from mobile phone accelerometer and gyroscope signals, this paper examined various phone carrying positions and switching positions as the research objective and analysed the time domain characteristics of the three-axis accelerometer and gyroscope signals. A principal component analysis algorithm was used to reduce the dimension of the extracted multidimensional gait feature, and the extracted features were random forest modelled to distinguish the phone carrying positions. The results show that the step detection and distance estimation accuracy in the gait detection process greatly improved after recognition of the phone carrying position, which enhanced the robustness of the PDR algorithm.
    Materialart: Online-Ressource
    ISSN: 1574-017X , 1875-905X
    URL: Article
    DOI: 10.1155/2019/4709501
    RVK:
    QA 10000
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2187808-0
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    HO-1/PINK1 Regulated Mitochondrial Fusion/Fission to Inhibit Pyroptosis and Attenuate Septic Acute Kidney Injury
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-10-22), p. 1-14
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-10-22), p. 1-14
    Kurzfassung: Background. Endotoxin-associated acute kidney injury (AKI), a disease characterized by marked oxidative stress and inflammation disease, is a major cause of mortality in critically ill patients. Mitochondrial fission and pyroptosis often occur in AKI. However, the underlying biological pathways involved in endotoxin AKI remain poorly understood, especially those related to mitochondrial dynamics equilibrium disregulation and pyroptosis. Previous studies suggest that heme oxygenase- (HO-) 1 confers cytoprotection against AKI during endotoxic shock, and PTEN-induced putative kinase 1 (PINK1) takes part in mitochondrial dysfunction. Thus, in this study, we examine the roles of HO-1/PINK1 in maintaining the dynamic process of mitochondrial fusion/fission to inhibit pyroptosis and mitigate acute kidney injury in rats exposed to endotoxin. Methods. An endotoxin-associated AKI model induced by lipopolysaccharide (LPS) was used in our study. Wild-type (WT) rats and PINK1 knockout (PINK1KO) rats, respectively, were divided into four groups: the control, LPS, Znpp+LPS, and Hemin+LPS groups. Rats were sacrificed 6 h after intraperitoneal injecting LPS to assess renal function, oxidative stress, and inflammation by plasma. Mitochondrial dynamics, morphology, and pyroptosis were evaluated by histological examinations. Results. In the rats with LPS-induced endotoxemia, the expression of HO-1 and PINK1 were upregulated at both mRNA and protein levels. These rats also exhibited inflammatory response, oxidative stress, mitochondrial fission, pyroptosis, and decreased renal function. After upregulating HO-1 in normal rats, pyroptosis was inhibited; mitochondrial fission and inflammatory response to oxidative stress were decreased; and the renal function was improved. The effects were reversed by adding Znpp (a type of HO-1 inhibitor). Finally, after PINK1 knockout, there is no statistical difference in the LPS-treated group and Hemin or Znpp pretreated group. Conclusions. HO-1 inhibits inflammation response and oxidative stress and regulates mitochondria fusion/fission to inhibit pyroptosis, which can alleviate endotoxin-induced AKI by PINK1.
    Materialart: Online-Ressource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2020/2148706
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Facial Recognition of Cattle Based on SK-ResNet
    Hindawi Limited ; 2022
    In:  Scientific Programming Vol. 2022 ( 2022-11-2), p. 1-10
    Details
    In: Scientific Programming, Hindawi Limited, Vol. 2022 ( 2022-11-2), p. 1-10
    Kurzfassung: With the gradual increase of the scale of the breeding industry in recent years, the intelligence level of livestock breeding is also improving. Intelligent breeding is of great significance to the identification of livestock individuals. In this paper, the cattle face images are obtained from different angles to generate the cow face dataset, and a cow face recognition model based on SK_ResNet is proposed. Based on ResNet-50 and using a different number of sk_Bottleneck, this model integrates multiple receptive fields of information to extract facial features at multiple scales. The shortcut connection part connects to the maximum pooling layer to reduce information loss; the ELU activation function is used to reduce the vanishing gradient, prevent overfitting, accelerate the convergence speed, and improve the generalization ability of the model. The constructed bovine face dataset was used to train the SK-ResNet-based bovine face recognition model, and the accuracy rate was 98.42%. The method was tested on the public dataset and the self-built dataset. The accuracy rate of the model was 98.57% on the self-built pig face dataset and the public sheep face dataset. The accuracy rate was 97.02%. The experimental results verify the superiority of this method in practical application, which is helpful for the practical application of animal facial recognition technology in livestock.
    Materialart: Online-Ressource
    ISSN: 1875-919X , 1058-9244
    URL: Article
    DOI: 10.1155/2022/5773721
    RVK:
    SA 7860
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2070004-0
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Increased Serum Concentrations of TNF-Like Weak Inducer of Apoptosis Predict Higher 28-Day Mortality in Patients with Sepsis
    Hindawi Limited ; 2019
    In:  Emergency Medicine International Vol. 2019 ( 2019-01-10), p. 1-7
    Details
    In: Emergency Medicine International, Hindawi Limited, Vol. 2019 ( 2019-01-10), p. 1-7
    Kurzfassung: We performed the current study to explore potential predictive value of serum Tumor Necrosis Factor- (TNF-) like weak inducer of apoptosis (TWEAK) concentrations for 28-day mortality in patients with sepsis. Adult septic patients (age≥18 years) admitted to a general ICU between November 2016 and October 2017 were consecutively included in our prospective observational study. TWEAK concentrations were detected in septic patients and healthy controls. Dynamic changes of TWEAK concentrations between 1st day and 3rd day of admission to ICU (ΔTWEAK concentrations) were also measured. A total of 79 septic patients were included and 19 of them (24.1%) died after a follow-up period of 28 days. We identified arterial lactate, NT-proBNP, and male gender as independent factors for 28-day mortality of patients with sepsis. The serum levels of TWEAK were significantly lower in septic patients compared to controls (417.4 ± 196.7 pg/ml versus 1243.8 ± 174.3 pg/ml, p 〈 0.001). We found a positive correlation between TWEAK concentrations and SOFA score (Spearman correlation coefficient 0.235, p =0.037). Area under the receiver operating characteristic curve (AUROC) of ΔTWEAK concentrations for 28-day mortality was 0.754 (95% CI 0.645–0.844). We also evaluated the diagnostic performance of combinative index (ΔTWEAK concentrations and lactate) and obtained an AUROC of 0.860 (95% CI 0.763-0.928). In conclusion, our study found lower TWEAK concentrations in septic patients than those in healthy controls. Furthermore, the increased TWEAK concentrations during disease process predict higher 28-day mortality in septic patients. Dynamic changes of TWEAK should be an important supplement for current prognostic markers.
    Materialart: Online-Ressource
    ISSN: 2090-2840 , 2090-2859
    URL: Article
    DOI: 10.1155/2019/7238705
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2596429-X
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
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