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  • Wiley  (2)
  • Guo, Huan  (2)
  • Wei, Sheng  (2)
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  • Wiley  (2)
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  • 1
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 32, No. 1 ( 2016-01), p. 95-101
    Abstract: Although the association of Helicobacter pylori ( H .  pylori ) infection with diabetes mellitus has been evaluated, findings are controversial. This study investigated the association in a Chinese population. Methods A cross‐sectional study, including a total of 30 810 subjects from the Dongfeng‐Tongji Cohort study, was conducted. H .  pylori status was measured via 14 C urea breath test. Association analysis was performed by logistic regression, with multivariable adjustment for sex, age, body mass index, smoking, alcohol consumption, family history of diabetes, physical activity and the use of antibiotics. Results Among a middle‐age and old‐age Chinese population, individuals with H .  pylori infection also had a higher prevalence of type 2 diabetes (21.3% versus 20.2%, p  = 0.026). H .  pylori infection was associated with higher risk of type 2 diabetes [odds ratio, 1.08 (95% confidence interval: 1.02–1.14); p  = 0.008] after adjustment for other confounders. The association was significant among women, those who were above 65 years old, not overweight or obese, and those who did not smoke, did not consume alcohol and without family history of diabet es. However, there was no interaction between H .  pylori infection and other traditional risk factors on type 2 diabetes risk. Subjects with H .  pylori infection had a lower level of high‐density lipoprotein cholesterol ( p   〈  0.0001) and higher levels of blood pressure ( p   〈  0.001), total cholesterol, HbA 1c and fasting blood glucose ( p   〈  0.0001) than those who did not. Conclusions These findings suggested that H .  pylori infection was associated with the risk of type 2 diabetes in a middle‐age and old‐age Chinese population. Copyright © 2015 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2001565-3
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  • 2
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 36, No. 1 ( 2020-01)
    Abstract: We examined the association between metabolically healthy obese (MHO) and diabetes incidence in a middle‐aged and elderly population and whether the association differed by the presence of nonalcoholic fatty liver disease (NAFLD). Methods We examined 17 801 participants without diabetes at study entry (7980 males and 9821 females with a mean age of 63.2 years) derived from the Dongfeng‐Tongji cohort study (median follow‐up: 4.6 years). Participants were divided into six groups based on BMI (normal weight, overweight, or obese) and metabolic health (healthy/unhealthy) defined by the Adult Treatment Panel III criteria. The MHO was defined as BMI greater than 28.0 kg/m 2 with 0 or 1 of four metabolic abnormalities (elevated blood pressure, triglyceridaemia, hyperglycaemia, low HDL cholesterol). The hazard ratio (HR) and 95% confidence interval (CI) for incident diabetes were derived from the Cox proportional hazard regression model. Results During 79 843 person‐years of follow‐up, 1453 individuals developed diabetes. Compared with metabolically healthy normal weight (MH‐NW) individuals, the multivariable‐adjusted HRs (95% CI) were 1.74 (1.16‐2.59) for MHO and 2.15 (1.65‐2.81) for metabolically unhealthy obese subjects after adjusting for age, sex, smoking, alcohol drinking, physical activity, fruit and vegetable consumption, family history of diabetes, fasting glucose, waist circumference, and NAFLD. Among those without NAFLD, MHO individuals showed higher incidence of diabetes (multivariate‐adjusted HR = 2.71, 95% CI: 1.47‐5.00) than MH‐NW individuals. Conclusions The MHO phenotype was associated with increased incidence of diabetes in a middle‐aged and elderly population, and the association did not differ by the presence or absence of NAFLD.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001565-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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