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  • Wiley  (5)
  • Guan, Lina  (5)
  • 1
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    Online Resource
    ECHO provides layer‐specific insight of both myocardial deformation and microcirculation dysfunction in dilated cardiomyopathy patients: Clinical value of combined application of left ventricular layer‐specific strain and myocardial contrast echocardiography
    Wiley ; 2023
    In:  Journal of Clinical Ultrasound Vol. 51, No. 5 ( 2023-06), p. 753-761
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    In: Journal of Clinical Ultrasound, Wiley, Vol. 51, No. 5 ( 2023-06), p. 753-761
    Abstract: To investigate the pattern of left ventricular (LV) function and myocardial perfusion and their relationship in dilated cardiomyopathy (DCM) patients using layer‐specific speckle tracking imaging (STI) and layer‐specific myocardial contrast echocardiography (MCE). Material and Methods Thirty DCM patients and 30 controls were recruited and underwent STI and MCE examination. The peak values of longitudinal strain (LS), circumferential strain (CS) of each layer of LV were recorded and compared between groups. Additionally, cross‐sectional area of a microvessel (A) and average myocardial microvascular lesion (β) of each layer were measured, myocardial blood flow (MBF) was estimated using A × β, above parameters were compared between two groups. Results The LS of endo‐ (LS endo ), mid‐ (LS mid ) and epicardium (LS epi ), as well as CS of endo‐ (RS endo ), mid‐ (RS mid ), (LS epi ) epicardium and LS endo/epi, CS endo/epi were significantly decreased in DCM patients. More importantly, DCM patients demonstrated decreased A, β and A × β in all three myocardium layers and A endo/epi, β endo/epi, A × β endo/epi compared to the controls. The time to peak and the cardiac cycle required to reach the peak were prolonged in DCM patients ( p   〈  0.05). Longitudinal strain parameters of each layer had a negative relationship with perfusion parameter A and this relationship was strongest between LSendo and Aendo ( r  = 0.690, p   〈  0.01). Conclusions The cardiac strain and, more importantly, coronary microcirculation perfusion was impaired in each layer in DCM patients. The longitudinal function of the LV myocardium was closely related to changes in myocardial microcirculation perfusion.
    Type of Medium: Online Resource
    ISSN: 0091-2751 , 1097-0096
    URL: Issue
    URL: Article
    DOI: 10.1002/jcu.v51.5
    DOI: 10.1002/jcu.23419
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492376-2
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  • 2
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    Prognostic Value of Real Time Myocardial Contrast Echocardiography after Percutaneous Coronary Intervention
    Wiley ; 2016
    In:  Echocardiography Vol. 33, No. 3 ( 2016-03), p. 421-430
    Details
    In: Echocardiography, Wiley, Vol. 33, No. 3 ( 2016-03), p. 421-430
    Abstract: Real time myocardial contrast echocardiography (RTMCE) is a cost‐effective and simple method to quantify coronary flow reserve ( CFR ). We aimed to determine the value of RTMCE to predict cardiac events after percutaneous coronary intervention ( PCI ). We have studied myocardial blood volume (A), velocity ( β ), flow indexes ( MBF , A × β ), and vasodilator reserve (stress‐to‐rest ratios) in 36 patients with acute coronary syndrome ( ACS ) who underwent PCI . CFR ( MBF at stress/ MBF at rest) was calculated for each patient. Perfusion scores were used for visual interpretation by MCE and correlation with TIMI flow grade. In qualitative RTMCE assessment, post‐ PCI visual perfusion scores were higher than pre‐ PCI (Z = −7.26, P 〈 0.01). Among 271 arteries with TIMI flow grade 3 post‐ PCI , 72 (36%) did not reach visual perfusion score 1. The β ‐ and A × β ‐reserve of the abnormal segments supplied by obstructed arteries increased after PCI comparing to pre‐ PCI values (P 〈 0.01). Patients with adverse cardiac events had significantly lower β ‐ and lower A × β ‐reserve than patients without adverse cardiac events. In the former group, the CFR was ≥ 1.5 both pre‐ and post‐ PCI . CFR estimation by RTMCE can quantify myocardial perfusion in patients with ACS who underwent PCI . The parameters β ‐reserve and CFR combined might predict cardiac events on the follow‐up.
    Type of Medium: Online Resource
    ISSN: 0742-2822 , 1540-8175
    URL: Issue
    URL: Article
    DOI: 10.1111/echo.2016.33.issue-3
    DOI: 10.1111/echo.13061
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2041033-5
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  • 3
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    A canine acute coronary occlusion model using thrombus implantation by percutaneous coronary intervention
    Wiley ; 2023
    In:  iRADIOLOGY Vol. 1, No. 4 ( 2023-12), p. 294-302
    Details
    In: iRADIOLOGY, Wiley, Vol. 1, No. 4 ( 2023-12), p. 294-302
    Abstract: To establish an acute canine coronary artery occlusion model by implanting a mixed thrombus prepared in vitro into the coronary artery by percutaneous coronary intervention (PCI). Methods This study included 14 healthy Beagle dogs aged 10–13 months. First, 5 ml of canine venous blood was drawn to prepare the coronary artery thrombus in vitro. The thrombus was then implanted into the canine coronary artery by PCI to establish an animal model of acute coronary artery occlusion. Dogs were randomly divided into two experimental groups: group A, in which dogs were assessed for 2 h after coronary occlusion, and group B, in which dogs were assessed for 4 h after surgery. Baseline and postoperative assessment included cardiac troponin T (cTnT) levels, electrocardiography (ECG), plain and contrast echocardiography, and large‐scale digital subtraction angiography (DSA). Results Canine venous blood was successfully used to prepare a mixed thrombus with reticular fibrin structure and activated platelets in vitro. After the mixed thrombus was implanted into the coronary artery, large‐scale DSA showed no contrast medium perfusion, confirming complete occlusion of the coronary artery. After the coronary artery occlusion, dogs in both groups showed ST segment elevation 〉 0.5 MV, a 0.9 μg/L increase in CTnT ( p   〈  0.001), and increased EDV and ESV. Dogs also showed decreased left ventricular EF and FS and decreased MBF in the infarcted area ( p   〈  0.05). Conclusions An experimental model of acute coronary artery occlusion in dogs was successfully established by implanting a mixed thrombus developed in vitro into the coronary artery using minimally invasive PCI.
    Type of Medium: Online Resource
    ISSN: 2834-2860 , 2834-2879
    URL: Issue
    URL: Article
    DOI: 10.1002/ird3.v1.4
    DOI: 10.1002/ird3.38
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 4
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    Online Resource
    The Value of Aneurysm Volume and Myocardial Strain Rate for Evaluating Cardiac Function of Ischemia‐Related Left Ventricular Aneurysm in a Rabbit Model Using Real Time Three‐Dimensional Echocardiographic Imaging Combined with Speckle Tracking Imaging
    Wiley ; 2013
    In:  Echocardiography Vol. 30, No. 7 ( 2013-08), p. 837-842
    Details
    In: Echocardiography, Wiley, Vol. 30, No. 7 ( 2013-08), p. 837-842
    Abstract: The aim of this study was to evaluate the effect of left ventricular aneurysm ( LVA ) volume and myocardial strain on left ventricular function in a rabbit model using real time three‐dimensional echocardiographic imaging ( RT‐3DE ) combined with two‐dimensional speckle tracking imaging ( 2D‐STI ). Methods A rabbit model of LVA was prepared in 30 N ew Z ealand rabbits by ligating the middle segment of the left anterior descending artery and the left circumflex artery ( LVA group); 10 control rabbits underwent thoracotomy alone. Four weeks later, RT‐3DE was performed to obtain data on left ventricular ejection fraction ( LVEF ), left ventricular end‐diastolic volume ( LVEDV ), left ventricular end‐systolic volume ( LVESV ), and LVA volume. The peak short‐axis radial ( SrR ) and circumferential ( SrC ) strain rates were measured using 2D‐STI technique. Results Compared with control rabbits, LVA group rabbits had significant left ventricular enlargement at the end‐systolic and end‐diastolic phases (both P  〈  0.05). LVEF , SrR ‐ S ystolic, and SrC ‐ S ystolic were significantly lower in the LVA group (all P  〈  0.05). Moreover, there were high correlations between LVEF and SrC ‐ S ystolic anterior wall , SrR ‐ S ystolic anterior wall , SrC ‐ S ystolic lateral wall , and SrR ‐ S ystolic lateral wall (r = −0.895, −0.887, −0.890, −0.891, respectively, all P  〈  0.05). Of note, LVA volume/ LVEDV had the tightest inverse relationship with LVEF (r = −0.911, P  〈  0.01). Specifically, LVA volume/ LVEDV 〉 16% corresponded to LVEF 〈 50%, and LVEF decreased 1.1% while LVA volume/ LVEDV increased 1%. Conclusions LVA volume/ LVEDV provided a sensitive indicator reflecting cardiac function with LVA . Measurement of various parameters using RT‐3DE might be a useful means to evaluate cardiac function after LVA formation.
    Type of Medium: Online Resource
    ISSN: 0742-2822 , 1540-8175
    URL: Issue
    URL: Article
    DOI: 10.1111/echo.2013.30.issue-7
    DOI: 10.1111/echo.12144
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2041033-5
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  • 5
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    Online Resource
    Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction: A meta‐analysis
    Wiley ; 2021
    In:  Clinical Cardiology Vol. 44, No. 12 ( 2021-12), p. 1683-1691
    Details
    In: Clinical Cardiology, Wiley, Vol. 44, No. 12 ( 2021-12), p. 1683-1691
    Abstract: Valvular dysfunction is a common complication in patients with bicuspid aortic valves (BAV). The aim of this study was to determine the relationship between BAV morphology patterns and valve dysfunction. Methods We searched the PubMed, The Cochrane Library, Web of Science, and CNKI until May 31, 2020, to identify all studies investigating the morphology of BAV and valvular dysfunction, and data were extracted according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA). Data were analyzed using Stata 15.1 software. The additional characteristics (gender, mean age) were collected to perform a meta‐regression analysis. Results Thirteen studies on BAV‐RL ( n  = 2002) versus BAV‐RN ( n  = 1254) and raphe ( n  = 4001) versus without raphe ( n  = 673) were included. The BAV‐RL patients showed a higher incidence of aortic regurgitation than BAV‐RN patients (OR = 1.46; 95% CI: 1.12 to 1.90, p  = .005), while the BAV‐RL patients showed a lower incidence of aortic stenosis than BAV‐RN patients (OR = 0.66, 95% CI: 0.58 to 0.76, p  = .000); BAV patients with raphe presents a higher incidence of aortic regurgitation than those without raphe (OR = 1.95, 95% CI: 1.12–3.39, p  = .017). No differences were found between raphe and without raphe group in the incidence of aortic stenosis (OR = 0.97, 95% CI: 0.53 to 1.76, p  = .907). Mean age and gender had no influence on observed differences. Conclusions Our results confirmed a relationship between different BAV phenotypes and aortic valve dysfunction. BAV‐RL and BAV with raphe are more likely to develop aortic regurgitation, while patients with BAV‐RN present a higher possibility to develop aortic stenosis.
    Type of Medium: Online Resource
    ISSN: 0160-9289 , 1932-8737
    URL: Issue
    URL: Article
    DOI: 10.1002/clc.v44.12
    DOI: 10.1002/clc.23736
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2048223-1
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