In:
PLOS Biology, Public Library of Science (PLoS), Vol. 20, No. 6 ( 2022-6-1), p. e3001653-
Abstract:
In contrast to the adult mammalian central nervous system (CNS), the neurons in the peripheral nervous system (PNS) can regenerate their axons. However, the underlying mechanism dictating the regeneration program after PNS injuries remains poorly understood. Combining chemical inhibitor screening with gain- and loss-of-function analyses, we identified p90 ribosomal S6 kinase 1 (RSK1) as a crucial regulator of axon regeneration in dorsal root ganglion (DRG) neurons after sciatic nerve injury (SNI). Mechanistically, RSK1 was found to preferentially regulate the synthesis of regeneration-related proteins using ribosomal profiling. Interestingly, RSK1 expression was up-regulated in injured DRG neurons, but not retinal ganglion cells (RGCs). Additionally, RSK1 overexpression enhanced phosphatase and tensin homolog (PTEN) deletion-induced axon regeneration in RGCs in the adult CNS. Our findings reveal a critical mechanism in inducing protein synthesis that promotes axon regeneration and further suggest RSK1 as a possible therapeutic target for neuronal injury repair.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001653
DOI:
10.1371/journal.pbio.3001653.g001
DOI:
10.1371/journal.pbio.3001653.g002
DOI:
10.1371/journal.pbio.3001653.g003
DOI:
10.1371/journal.pbio.3001653.g004
DOI:
10.1371/journal.pbio.3001653.g005
DOI:
10.1371/journal.pbio.3001653.g006
DOI:
10.1371/journal.pbio.3001653.g007
DOI:
10.1371/journal.pbio.3001653.g008
DOI:
10.1371/journal.pbio.3001653.s001
DOI:
10.1371/journal.pbio.3001653.s002
DOI:
10.1371/journal.pbio.3001653.s003
DOI:
10.1371/journal.pbio.3001653.s004
DOI:
10.1371/journal.pbio.3001653.s005
DOI:
10.1371/journal.pbio.3001653.s006
DOI:
10.1371/journal.pbio.3001653.s007
DOI:
10.1371/journal.pbio.3001653.s008
DOI:
10.1371/journal.pbio.3001653.s009
DOI:
10.1371/journal.pbio.3001653.s010
DOI:
10.1371/journal.pbio.3001653.s011
DOI:
10.1371/journal.pbio.3001653.s012
DOI:
10.1371/journal.pbio.3001653.s013
DOI:
10.1371/journal.pbio.3001653.s014
DOI:
10.1371/journal.pbio.3001653.s015
DOI:
10.1371/journal.pbio.3001653.s016
DOI:
10.1371/journal.pbio.3001653.s017
DOI:
10.1371/journal.pbio.3001653.s018
DOI:
10.1371/journal.pbio.3001653.s019
DOI:
10.1371/journal.pbio.3001653.s020
DOI:
10.1371/journal.pbio.3001653.s021
DOI:
10.1371/journal.pbio.3001653.s022
DOI:
10.1371/journal.pbio.3001653.s023
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2126773-X
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