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  • Gu, Xiaobin  (13)
  • 2020-2024  (13)
  • 1
    Online Resource
    Online Resource
    A Comparative Genomic Approach to Determine the Virulence Factors and Horizontal Gene Transfer Events of Clinical Acanthamoeba Isolates
    American Society for Microbiology ; 2022
    In:  Microbiology Spectrum Vol. 10, No. 2 ( 2022-04-27)
    Details
    In: Microbiology Spectrum, American Society for Microbiology, Vol. 10, No. 2 ( 2022-04-27)
    Abstract: Acanthamoeba species are among the most ubiquitous protists that are widespread in soil and water and act as both a replicative niche and vectors for dispersal. They are the most important human intracellular pathogens, causing Acanthamoeba keratitis (AK) and severely damaging the human cornea. The sympatric lifestyle within the host and amoeba-resisting microorganisms (ARMs) promotes horizontal gene transfer (HGT). However, the genomic diversity of only A. castellanii and A. polyphaga has been widely studied, and the pathogenic mechanisms remain unknown. Thus, we examined 7 clinically pathogenic strains by comparative genomic, phylogenetic, and rhizome gene mosaicism analyses to explore amoeba–symbiont interactions that possibly contribute to pathogenesis. Genetic characterization and phylogenetic analysis showed differences in functional characteristics between the “open” state of T3 and T4 isolates, which may contribute to the differences in virulence and pathogenicity. Through comparative genomic analysis, we identified potential genes related to virulence, such as metalloprotease, laminin-binding protein, and HSP, that were specific to the genus Acanthamoeba . Then, analysis of putative sequence trafficking between Acanthamoeba and Pandoraviruses or Acanthamoeba castellanii medusaviruses provided the best hits with viral genes; among bacteria, Pseudomonas had the most significant numbers. The most parsimonious evolutionary scenarios were between Acanthamoeba and endosymbionts; nevertheless, in most cases, the scenarios are more complex. In addition, the differences in exchanged genes were limited to the same family. In brief, this study provided extensive data to suggest the existence of HGT between Acanthamoeba and ARMs, explaining the occurrence of diseases and challenging Darwin’s concept of eukaryotic evolution. IMPORTANCE Acanthamoeba has the ability to cause serious blinding keratitis. Although the prevalence of this phenomenon has increased in recent years, our knowledge of the underlying opportunistic pathogenic mechanism maybe remains incomplete. In this study, we highlighted the importance of Pseudomonas in the pathogenesis pathway using comprehensive a whole genomics approach of clinical isolates. The horizontal gene transfer events help to explain how endosymbionts contribute Acanthamoeba to act as an opportunistic pathogen. Our study opens up several potential avenues for future research on the differences in pathogenicity and interactions among clinical strains.
    Type of Medium: Online Resource
    ISSN: 2165-0497
    URL: Article
    DOI: 10.1128/spectrum.00025-22
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2022
    detail.hit.zdb_id: 2807133-5
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  • 2
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    A versatile solar-powered vapor generating membrane for multi-media purification
    Elsevier BV ; 2021
    In:  Separation and Purification Technology Vol. 260 ( 2021-04), p. 117952-
    Details
    In: Separation and Purification Technology, Elsevier BV, Vol. 260 ( 2021-04), p. 117952-
    Type of Medium: Online Resource
    ISSN: 1383-5866
    URL: Article
    DOI: 10.1016/j.seppur.2020.117952
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2022535-0
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  • 3
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    Fabrication of a novel shape-stabilized composite phase change material based on multivariate supporting materials by using typical solid wastes
    Elsevier BV ; 2020
    In:  Construction and Building Materials Vol. 240 ( 2020-04), p. 118156-
    Details
    In: Construction and Building Materials, Elsevier BV, Vol. 240 ( 2020-04), p. 118156-
    Type of Medium: Online Resource
    ISSN: 0950-0618
    URL: Article
    DOI: 10.1016/j.conbuildmat.2020.118156
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2002804-0
    detail.hit.zdb_id: 58896-9
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  • 4
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    Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592093742-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592093742-
    Abstract: Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC via meta-analysis. Methods: A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC. Results: A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21–2.13, p = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26–2.39, p = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27–2.02, p  〈  0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10–4.67, p = 0.026), ECOG PS of 1–2 (OR = 1.98, 95% CI = 1.39–2.84, p  〈  0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18–1.88, p = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC. Conclusion: Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920937425
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 5
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    〈p〉MiR-499a-5p Inhibits Pr5/4/20 publish l Cancer Cells via Targeting eIF4E〈/p〉
    Informa UK Limited ; 2020
    In:  OncoTargets and Therapy Vol. Volume 13 ( 2020-04), p. 2913-2924
    Details
    In: OncoTargets and Therapy, Informa UK Limited, Vol. Volume 13 ( 2020-04), p. 2913-2924
    Type of Medium: Online Resource
    ISSN: 1178-6930
    URL: Article
    DOI: 10.2147/OTT.S241631
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2495130-4
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  • 6
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    Table_1.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Microbiology Vol. 12 ( 2021-11-15)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 12 ( 2021-11-15)
    Abstract: Coagulase-negative Staphylococcus (CoNS) is the most common pathogen causing traumatic endophthalmitis. Among which, Staphylococcus epidermidis is the most common species that colonizes human skin, eye surfaces, and nasal cavity. It is also the main cause of nosocomial infection, specially foreign body-related bloodstream infections (FBR-BSIs). Although some studies have reported the genome characteristics of S. epidermidis , the genome of ocular trauma-sourced S. epidermidis strain and a comprehensive understanding of its pathogenicity are still lacking. Our study sequenced, analyzed, and reported the whole genomes of 11 ocular trauma-sourced samples of S. epidermidis that caused traumatic endophthalmitis. By integrating publicly available genomes, we obtained a total of 187 S. epidermidis samples from healthy and diseased eyes, skin, respiratory tract, and blood. Combined with pan-genome, phylogenetic, and comparative genomic analyses, our study showed that S. epidermidis , regardless of niche source, exhibits two founder lineages with different pathogenicity. Moreover, we identified several potential biomarkers associated with the virulence of S. epidermidis , including essD , uhpt , sdrF , sdrG , fbe , and icaABCDR . EssD and uhpt have high homology with esaD and hpt in Staphylococcus aureus , showing that the genomes of S. epidermidis and S. aureus may have communicated during evolution. SdrF , sdrG , fbe , and icaABCDR are related to biofilm formation. Compared to S. epidermidis from blood sources, ocular-sourced strains causing intraocular infection had no direct relationship with biofilm formation. In conclusion, this study provided additional data resources for studies on S. epidermidis and improved our understanding of the evolution and pathogenicity among strains of different sources.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2021.770191
    DOI: 10.3389/fmicb.2021.770191.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587354-4
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  • 7
    Online Resource
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    Pan‐cancer analyses of immunogenic cell death‐derived gene signatures: Potential biomarkers for prognosis and immunotherapy
    Wiley ; 2024
    In:  Cancer Reports Vol. 7, No. 4 ( 2024-04)
    Details
    In: Cancer Reports, Wiley, Vol. 7, No. 4 ( 2024-04)
    Abstract: Immunogenic cell death (ICD) is a type of regulated cell death that is capable of initiating an adaptive immune response. Induction of ICD may be a potential treatment strategy, as it has been demonstrated to activate the tumor‐specific immune response. Aims The biomarkers of ICD and their relationships with the tumor microenvironment, clinical features, and immunotherapy response are not fully understood in a clinical context. Therefore, we conducted pan‐cancer analyses of ICD gene signatures across 33 cancer types from The Cancer Genome Atlas database. Methods and Results We identified key genes that had strong relationships with survival and the tumor microenvironment, contributing to a better understanding of the role of ICD genes in cancer therapy. In addition, we predicted therapeutic agents that target ICD genes and explored the potential mechanisms by which gemcitabine induce ICD. Moreover, we developed an ICD score based on the ICD genes and found it to be associated with patient prognosis, clinical features, tumor microenvironment, radiotherapy access, and immunotherapy response. A high ICD score was linked to the immune‐hot phenotype, while a low ICD score was linked to the immune‐cold phenotype. Conclusion We uncovered the potential of ICD gene signatures as comprehensive biomarkers for ICD in pan‐cancer. Our research provides novel insights into immuno‐phenotypic assessment and cancer therapeutic strategies, which could help to broaden the application of immunotherapy to benefit more patients.
    Type of Medium: Online Resource
    ISSN: 2573-8348 , 2573-8348
    URL: Issue
    URL: Article
    DOI: 10.1002/cnr2.v7.4
    DOI: 10.1002/cnr2.2073
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2920367-3
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  • 8
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    A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
    Springer Science and Business Media LLC ; 2020
    In:  Cancer Cell International Vol. 20, No. 1 ( 2020-12)
    Details
    In: Cancer Cell International, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Programmed death-ligand 1 (PD-L1) was the first identified ligand of programmed death-1 (PD-1). PD-1/PD-L1 interactions inhibit T cell-mediated immune responses, limit cytokine production, and promote tumor immune escape. Recently, many studies have investigated the prognostic value of PD-L1 expression in patients with melanoma. However, the results of these analyses remain a subject of debate. We have therefore carried out a meta-analysis to identify the prognostic role of PD-L1 in melanoma. Methods A thorough medical literature search was performed in the databases PubMed, Web of Science, and Embase until October 2019. The pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated to evaluate the correlation between PD-L1 overexpression and prognosis. Publication bias was evaluated using Begg’s test and Egger’s test. Results Thirteen articles with 1062 enrolled patients were included in this meta-analysis. High PD-L1 expression did not correlate with overall survival (OS) (HR = 0.93, 95% CI 0.57–1.52, P = 0.781) or progression-free survival (PFS) (HR = 0.82, 95% CI 0.43–1.54, P = 0.535). However, PD-L1 overexpression correlated with the absence of lymph node (LN) metastasis (OR = 0.46, 95% CI 0.22–0.95, P = 0.036). Further, there was no significant relationship between PD-L1 expression and sex (OR = 1.29, 95% CI 0.90–1.84, P = 0.159), age (OR = 0.90, 95% CI 0.51–1.57, P = 0.708), or Eastern Cooperative Oncology Group Performance Status (OR = 0.55, 95% CI 0.06–4.83, P = 0.592). Conclusions This meta-analysis suggested that PD-L1 expression did not predict an inferior prognosis in patients with melanoma. However, high PD-L1 expression was associated with absence of LN metastasis in such patients.
    Type of Medium: Online Resource
    ISSN: 1475-2867
    URL: Article
    DOI: 10.1186/s12935-020-01187-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2091573-1
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  • 9
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    LncRNA MEG3 regulates breast cancer proliferation and apoptosis through miR-141-3p/RBMS3 axis
    Elsevier BV ; 2021
    In:  Genomics Vol. 113, No. 4 ( 2021-07), p. 1689-1704
    Details
    In: Genomics, Elsevier BV, Vol. 113, No. 4 ( 2021-07), p. 1689-1704
    Type of Medium: Online Resource
    ISSN: 0888-7543
    URL: Article
    DOI: 10.1016/j.ygeno.2021.04.015
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1468023-3
    SSG: 12
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  • 10
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    Simple Nonfused‐Ring Electron Acceptors with Noncovalently Conformational Locks for Low‐Cost and High‐Performance Organic Solar Cells Enabled by End‐Group Engineering
    Wiley ; 2022
    In:  Advanced Functional Materials Vol. 32, No. 5 ( 2022-01)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 32, No. 5 ( 2022-01)
    Abstract: The rapid advance of fused‐ring electron acceptors (FREAs) has greatly promoted the leap‐forward development of organic solar cells (OSCs). However, the synthetic complexity of FREAs may be detrimental for future commercial applications. Recently, nonfused‐ring electron acceptors (NREAs) have been developed to be a promising candidate to maintain a rational balance between cost and performance, of which the cores are composed of simple fused rings (NREAs‐I) or nonfused rings (NREAs‐II). Moreover, “noncovalently conformational locks”, are used as an effective strategy to enhance the rigidity and planarity of NREAs and improve device performance. Herein, a novel series of NREAs‐II (PhO4T‐1, PhO4T‐2, and PhO4T‐3) is constructed as a valuable platform for exploring the impact of the end group engineering on optoelectronic properties, intermolecular packing behaviors, and device performance. As a result, a high power conversion efficiency of 13.76% is achieved for PhO4T‐3 based OSCs, which is much higher than those of the PhO4T‐1 and PhO4T‐2‐based devices. Compared with several representative FREAs, PhO4T‐3 possesses the highest figure‐of‐merit value of 133.45 based on a cost‐efficiency evaluation. This work demonstrates that the simple‐structured NREAs‐II are promising candidates for low‐cost and high‐performance OSCs.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v32.5
    DOI: 10.1002/adfm.202108861
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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