In:
Toxins, MDPI AG, Vol. 11, No. 5 ( 2019-05-13), p. 268-
Abstract:
Connective tissue growth factor (CTGF) plays a key role in the pathogenesis of tissue fibrosis. The aminoterminal fragment of CTGF is a middle molecule that accumulates in chronic kidney disease. The aims of this study are to explore determinants of plasma CTGF in hemodialysis (HD) patients, investigate whether CTGF relates to all-cause mortality in HD patients, and investigate whether online-hemodiafiltration (HDF) lowers CTGF. Data from 404 patients participating in the CONvective TRAnsport STudy (CONTRAST) were analyzed. Patients were randomized to low-flux HD or HDF. Pre-dialysis CTGF was measured by sandwich ELISA at baseline, after six and 12 months. CTGF was inversely related in multivariable analysis to glomerular filtration rate (GFR) (p 〈 0.001) and positively to cardiovascular disease (CVD) (p = 0.006), dialysis vintage (p 〈 0.001), interleukin-6 (p 〈 0.001), beta-2-microglobulin (p = 0.045), polycystic kidney disease (p 〈 0.001), tubulointerstitial nephritis (p = 0.002), and renal vascular disease (p = 0.041). Patients in the highest quartile had a higher mortality risk compared to those in the lowest quartile (HR 1.7, 95% CI: 1.02–2.88, p = 0.043). HDF lowered CTGF with 4.8% between baseline and six months, whereas during HD, CTGF increased with 4.9% (p 〈 0.001). In conclusion, in HD patients, CTGF is related to GFR, CVD and underlying renal disease and increased the risk of all-cause mortality. HDF reduces CTGF.
Type of Medium:
Online Resource
ISSN:
2072-6651
DOI:
10.3390/toxins11050268
Language:
English
Publisher:
MDPI AG
Publication Date:
2019
detail.hit.zdb_id:
2518395-3
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