In:
Zeitschrift für Naturforschung B, Walter de Gruyter GmbH, Vol. 72, No. 1 ( 2017-1-1), p. 11-15
Abstract:
Bio-guided fractionation of the guggul gum resin of Commiphora mukul HOOK using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay for the breast cancer cell line MDA-MB-231 led to the isolation of a new C17 norditerpene named myrrhanone C ( 1 ) along with two known polypodane-type triterpenes, namely, myrrhanone B ( 2 ) and myrrhanol B ( 3 ). The structures of the isolated compounds were elucidated by means of 1D ( 1 H and 13 C) and 2D (correlation spectroscopy, heteronuclear single-quantum coherence, heteronuclear multiple-bond correlation, and nuclear Overhauser effect spectroscopy) NMR spectroscopy as well as mass (electrospray ionization-mass spectroscopy) spectral analyses. Interestingly myrrhanone C ( 1 ) was able to induce a substantial decline in cell proliferation. It reduced the viability of cancer cells by almost 81% and 87% at concentrations of 50 and 100 μg mL −1 , respectively. Myrrhanone B ( 2 ) and myrrhanol B ( 3 ) showed a concentration-dependent growth inhibitory effect on cancer cells, with the latter being slightly more cytotoxic than the former at both the concentrations tested. Furthermore, myrrhanone C ( 1 ) and myrrhanone B ( 2 ) showed good α-glucosidase and urease inhibition.
Type of Medium:
Online Resource
ISSN:
1865-7117
,
0932-0776
DOI:
10.1515/znb-2016-0062
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2017
detail.hit.zdb_id:
2078109-X
detail.hit.zdb_id:
124635-5
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