In:
Current Pharmaceutical Design, Bentham Science Publishers Ltd., Vol. 24, No. 10 ( 2018-05-28), p. 1121-1129
Abstract:
Since the initial description of granular-rich small-intestinal crypt-based epithelial cells in 1872, today
referred to as Paneth cells, a plethora of recent studies underlined their function in intestinal homeostasis. Paneth cells are evolutionary conserved highly secretory cells that produce antimicrobials to control gut microbial communities.
Moreover, Paneth cells emerged as stem cell regulators that translate environmental cues into intestinal epithelial responses. Paneth cell disturbances may instigate intestinal inflammation and provide susceptibility to
infection. Altered Paneth cell functions have been associated with a variety of inflammatory disease models and were linked to human intestinal disease processes including inflammatory bowel diseases such as Crohn´s disease
and ulcerative colitis. This review summarizes our current understanding of Paneth cells and their antimicrobials in health and disease.
Type of Medium:
Online Resource
ISSN:
1381-6128
DOI:
10.2174/1381612824666180327161947
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2018
SSG:
15,3
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