In:
Journal of Viral Hepatitis, Wiley, Vol. 15, No. 2 ( 2008-02), p. 129-136
Abstract:
Summary. Hepatic steatosis is common in hepatitis C virus (HCV)‐infected patients and may be associated with the metabolic syndrome. We studied steatosis in patients treated with peginterferonα‐2a plus ribavirin. Forty‐five of 207 patients (22%) had 〉 5% hepatic steatosis at baseline. Significantly more patients with steatosis than without were HCV genotype 3 (51% vs 14%; P 〈 0.0001) had higher HCV‐RNA ( P = 0.0045), body weight ( P = 0.0176), body mass index (BMI, P = 0.0352) and serum triglycerides (TG) ( P = 0.0364), hypertriglyceridaemia ( P = 0.0009), elevated blood pressure/history of hypertension ( P = 0.0229) and lower cholesterol ( P = 0.0009). Significant steatosis predictors were genotype 3 (OR 9.04, 95% CI 3.85–21.21, P 〈 0.0001), HCV‐RNA (OR 2.96, 1.49–5.88, P = 0.0019) and triglycerides (OR 1.06, 1.02–1.11, P = 0.0071). In genotype 3 patients, HCV‐RNA was the only significant predictor (OR 11.15, 2.60–47.81, P = 0.0012). In non‐genotype 3 patients, hypertriglyceridaemia was the only significant predictor (OR 1.07, 1.02–1.12, P = 0.0041). 134 of 207 patients (65%) achieved an sustained virological response (SVR) with peginterferon α‐2a plus ribavirin, similar to the overall response rate. In genotype 3 patients with an SVR, steatosis decreased from 48% to 13% (baseline to end‐point). No change was seen in the steatosis rate in non‐genotype 3 patients with an SVR. This large and comprehensive analysis of a large data base from a multinational trial further adds to the observations that chronic HCV is associated with hepatic steatosis in approximately a fifth of patients. Further, features of the metabolic syndrome are associated with hepatic steatosis in most of these patients. Steatosis is significantly more common in genotype 3 compared with other genotypes, and in these patients, an SVR is associated with steatosis clearance.
Type of Medium:
Online Resource
ISSN:
1352-0504
,
1365-2893
DOI:
10.1111/jvh.2008.15.issue-2
DOI:
10.1111/j.1365-2893.2007.00901.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2007924-2
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