In:
Journal of Thoracic Imaging, Ovid Technologies (Wolters Kluwer Health), Vol. 38, No. 3 ( 2023-05), p. 145-153
Abstract:
To evaluate the accuracy of a deep learning-based computer-aided detection (CAD) system in identifying active pulmonary tuberculosis on chest radiographs (CRs) of patients with positive interferon-gamma release assay (IGRA) results in different scenarios of clinical implementation. Materials and Methods: We collected the CRs of consecutive patients with positive IGRA results. Findings of active pulmonary tuberculosis on CRs were independently evaluated by the CAD and a thoracic radiologist, followed by interpretation using the CAD. Sensitivity and specificity were evaluated in different scenarios: (a) radiologists’ interpretation, (b) radiologists’ CAD-assisted interpretation, and (c) CAD-based prescreening (radiologists’ interpretation for positive CAD results only). We conducted a reader test to compare the accuracy of the CAD with those of 5 radiologists. Results: Among 1780 patients (men, 53.8%; median age, 56 y), 44 (2.5%) were diagnosed with active pulmonary tuberculosis. The CAD-assisted interpretation exhibited a higher sensitivity (81.8% vs. 72.7%; P =0.046) but lower specificity than the radiologists’ interpretation (84.1% vs. 85.7%; P 〈 0.001). The CAD-based prescreening exhibited a higher specificity than the radiologists’ interpretation (88.8% vs. 85.7%; P 〈 0.001) at the same sensitivity, with a workload reduction of 85.2% (1780 to 263). In the reader test, the CAD exhibited a higher sensitivity than radiologists (72.7% vs. 59.5%; P =0.005) at the same specificity (88.0%), and CAD-assisted interpretation significantly improved the sensitivity of radiologists’ interpretation (72.3%; P 〈 0.001). Conclusions: For identifying active pulmonary tuberculosis among patients with positive IGRA results, deep learning-based CAD can enhance the sensitivity of interpretation. CAD-based prescreening may reduce the radiologists’ workload at an improved specificity.
Type of Medium:
Online Resource
ISSN:
0883-5993
DOI:
10.1097/RTI.0000000000000691
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
detail.hit.zdb_id:
2048799-X
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