In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 41, No. 6 ( 2021-06), p. 1338-1350
Abstract:
[ 11 C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A). The main objective of this study was to determine the 28-day test–retest repeatability (TRT) of quantitative [ 11 C]UCB-J brain positron emission tomography (PET) imaging in Alzheimer’s disease (AD) patients and healthy controls (HCs). Nine HCs and eight AD patients underwent two 60 min dynamic [ 11 C]UCB-J PET scans with arterial sampling with an interval of 28 days. The optimal tracer kinetic model was assessed using the Akaike criteria (AIC). Micro-/macro-parameters such as tracer delivery (K 1 ) and volume of distribution (V T ) were estimated using the optimal model. Data were also analysed for simplified reference tissue model (SRTM) with centrum semi-ovale (white matter) as reference region. Based on AIC, both 1T2k_V B and 2T4k_V B described the [ 11 C]UCB-J kinetics equally well. Analysis showed that whole-brain grey matte r TRT for V T , DVR and SRTM BP ND were –2.2% ± 8.5, 0.4% ± 12.0 and –8.0% ± 10.2, averaged over all subjects. [ 11 C]UCB-J kinetics can be well described by a 1T2k_V B model, and a 60 min scan duration was sufficient to obtain reliable estimates for both plasma input and reference tissue models. TRT for V T , DVR and BP ND was 〈 15% (1SD) averaged over all subjects and indicates adequate quantitative repeatability of [ 11 C]UCB-J PET.
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1177/0271678X20964248
Language:
English
Publisher:
SAGE Publications
Publication Date:
2021
detail.hit.zdb_id:
2039456-1
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