In:
Journal of Neuroimaging, Wiley, Vol. 23, No. 4 ( 2013-10), p. 484-488
Abstract:
The detection of microembolic signals in transcranial‐Doppler monitoring is associated with a higher stroke risk. We investigated the correlation between the frequency of microembolic signals and the efficacy of the antiplatelet therapy in patients with a recent symptomatic carotid‐artery stenosis. SUBJECTS AND METHODS Thirty‐two patients (mean age: 70 years, 22 men) with a recent symptomatic carotid‐artery stenosis underwent 30‐minute TCD‐monitoring. Twenty‐three patients received acetylsalicylic‐acid and 9 patients clopidogrel as antiplatelet‐therapy. At the same day, the antiplatelet effect was measured with multiple‐electrode‐impedance aggregometry. RESULTS In 20 cases, the qualifying event was a stroke and in 12 cases, a TIA. Twenty‐six of the patients had a 〉 50% degree of stenosis. More than one microembolic signals were detected in 13 (40.6%) of the subjects, while multiple‐electrode‐impedance aggregometry revealed eight low responders (6 acetylsalicylic‐acid, 2 clopidogrel). More than one microembolic signals were detected in 6 of the 8 (75.0%) patients with low response, but in only 7 of the 24 subjects (29.2%) with an effective antiplatelet treatment (sensitivity 75%, specificity 70.8%; Fisher's exact test: P = .038). CONCLUSIONS Our study suggests that in patients with recent symptomatic carotid‐artery stenosis the detection of more than one microembolic signals might serve as a useful marker for the effectiveness of the antiplatelet treatment.
Type of Medium:
Online Resource
ISSN:
1051-2284
,
1552-6569
DOI:
10.1111/jon.2013.23.issue-4
DOI:
10.1111/j.1552-6569.2012.00770.x
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2035400-9
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