In:
Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 31, No. 1_Supplement ( 2022-01-01), p. PR-03-PR-03
Abstract:
Background: Structural racism has been associated with breast cancer mortality. Exposure to adverse inequities may drive epigenetic perturbations that affect racial disparities in breast cancer outcomes. This study examined the association between neighborhood-level redlining and DNA methylation in non-Hispanic Black and White women diagnosed with breast cancer. Methods: Genome-wide DNA methylation was measured using the EPIC array in the tumor tissue of 84 women. Linear regression models were used to examine the association between neighborhood-level redlining and methylation, regressing β values for each cytosine-phosphate-guanine dinucleotide (CpG) site on redlining while adjusting for covariates. Redlining was derived for census tracts using the Home Mortgage Disclosure Act database. We used a false discovery rate (FDR) threshold & lt;0.1, and for CpGs below this threshold, we examined interactions with Estrogen Receptor (ER) status. We employed multivariable Cox-proportional hazard models to estimate whether aberrant methylation was associated with all-cause mortality. Results: 36 of the CpG sites were associated with neighborhood-level redlining (FDR & lt;0.1). The majority of genes are implicated in carcinogenesis including genes in immune function (BANP, IGDCC3, GPR15), oncogenic signaling (IGFALS, RNLS, RTP3), and angiogenesis (ANGPT1). Further exploration of these 36 CpG sites revealed no interactions by ER status, no probes were associated with all-cause mortality. Conclusions: We identified novel associations between neighborhood-level redlining and the breast tumor DNA methylome. Our data are the first to show that structural racism impacts the breast tumor epigenome. Citation Format: Jasmine M Miller-Kleinhenz, Leah Moubadder, Kirsten M. Beyer, Yuhong Zhou, Anne H. Gaglioti, Jazib Gohar, Lindsay J. Collin, Kashari Henry, Karen M. Conneely, Uma Krishnamurti, Olivia D'Angelo, Keerthi Gogineni, Mylin Torres, Sheryl Gabram-Mendola, Lauren E. McCullough. Neighborhood-level redlining-associated methylation in breast tumors: The impact of structural racism on the tumor epigenome [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PR-03.
Type of Medium:
Online Resource
ISSN:
1055-9965
,
1538-7755
DOI:
10.1158/1538-7755.DISP21-PR-03
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2022
detail.hit.zdb_id:
2036781-8
detail.hit.zdb_id:
1153420-5
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