In:
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 276, No. 6 ( 1999-06-01), p. E1009-E1013
Abstract:
The aim of our study was to define the dose-response effect of a short-term treatment with different recombinant human growth hormone (rhGH) doses (1.25, 2.5, 5.0, 10.0, and 20.0 μg ⋅ kg −1 ⋅ day −1 for 4 days) on insulin-like growth factor I (IGF-I) and insulin-like growth factor-binding protein (IGFBP)-3 levels in 21 normal young adults of both sexes. The dose of 1.25 μg/kg rhGH did not modify IGF-I levels. The dose of 2.5 μg/kg rhGH significantly increased IGF-I levels in men ( P 〈 0.05) but not in women, whereas the higher doses increased IGF-I levels in both sexes ( P 〈 0.002). IGFBP-3 levels were not modified by 1.25 or 2.5 μg/kg rhGH in either sex. On the other hand, 5.0 μg/kg increased IGFBP-3 levels in men ( P 〈 0.05) but not in women, whereas the higher doses increased IGFBP-3 levels similarly in both sexes ( P 〈 0.02). In conclusion, our results demonstrate that IGF-I and IGFBP-3 responses to rhGH are dose and sex dependent. However, IGFBP-3 is less sensitive than IGF-I to rhGH stimulation.
Type of Medium:
Online Resource
ISSN:
0193-1849
,
1522-1555
DOI:
10.1152/ajpendo.1999.276.6.E1009
Language:
English
Publisher:
American Physiological Society
Publication Date:
1999
detail.hit.zdb_id:
1477331-4
SSG:
12
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