In:
Polymers for Advanced Technologies, Wiley, Vol. 30, No. 11 ( 2019-11), p. 2860-2871
Abstract:
In this study, a unique magnetic, pH, and thermo‐responsive hydrogel nanocomposite was synthesized via surface reversible addition fragmentation chain transfer (RAFT) copolymerization of acrylic acid (AA) and N‐isopropyl acrylamide (NIPAM) in the presence of magnetic β‐cyclodextrin (β‐CD). The nanocomposite demonstrated a pH‐responsiveness behavior at pHs 3 and 9. Moreover, swelling behaviors of nanocomposite were measured in solutions with various temperatures. Furthermore, the nanocomposites exhibited high swelling capacity by applying an external magnetic field because of the presence of Fe 3 O 4 nanoparticles in the polymer structure. Besides, the doxorubicin (DOX) loading and releasing behaviors of the hydrogel nanocomposites were studied because of the stimuli‐responsive properties of the synthesized carriers. The adsorption of DOX obeyed a pseudo‐second‐order model and fitted well to the Langmuir isotherm model with the maximum adsorption capacity uptake of 291 mg g −1 . In conclusion, the hydrogel nanocomposites were found to be as potential nanocarriers for use in controlled release applications.
Type of Medium:
Online Resource
ISSN:
1042-7147
,
1099-1581
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1481102-9
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