In:
Clinical Science, Portland Press Ltd., Vol. 48, No. s2 ( 1974-01-01), p. 65s-67s
Abstract:
1. The effects of propranolol and R03-4787, a new beta-adrenoceptor antagonist with a partial agonist activity, have been studied in a blind, cross-over comparison with placebo. 2. In ten patients who completed the study, the two drugs produced a similar reduction in blood pressure; the reduction in heart rate with propranolol was significantly(P0.001)greater than that produced by R03-4787. 3. Plasma renin activity averaged 4.13 ± 1.37 ng h−1ml−1 on placebo, fell to 3.64 ± 1.47 ng h−1ml−1 on propranolol and to 2.50 ± 1.39 ngh−1ml−1 on R03-4787. 4. No correlation was demonstrable between the log plasma concentration of either propranolol or R03-4787 and change in blood pressure.
Type of Medium:
Online Resource
ISSN:
0144-4107
Language:
English
Publisher:
Portland Press Ltd.
Publication Date:
1974
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