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  • Ge, Xiaoguang  (8)
  • Chemistry/Pharmacy  (8)
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  • Chemistry/Pharmacy  (8)
RVK
  • 1
    Online Resource
    Online Resource
    A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 3 ( 2021-01-18), p. 1326-1332
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 3 ( 2021-01-18), p. 1326-1332
    Abstract: The design of bright NIR‐II luminescent nanomaterials that enable efficient labelling of proteins without disturbing their physiological properties in vivo is challenging. We developed an efficient strategy to synthesize bright NIR‐II gold nanoclusters (Au NCs) protected by biocompatible cyclodextrin (CD). Leveraging the ultrasmall size of Au NCs ( 〈 2 nm) and strong macrocycle‐based host–guest chemistry, the as‐synthesized CD‐Au NCs can readily label proteins/antibodies. Moreover, the labelled proteins/antibodies enable highly efficient in vivo tracking during blood circulation, without disturbing their biodistribution and tumor targeting ability, thus leading to a sensitive tumor‐targeted imaging. CD‐Au NCs are stable in the harsh biological environment and show good biocompatibility and high renal clearance efficiency. Therefore, the NIR‐II biolabels developed in this study provide a promising platform to monitor the physiological behavior of biomolecules in living organisms.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.3
    DOI: 10.1002/ange.202010870
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Dual Ratiometric SERS and Photoacoustic Core–Satellite Nanoprobe for Quantitatively Visualizing Hydrogen Peroxide in Inflammation and Cancer
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 13 ( 2021-03-22), p. 7399-7408
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 13 ( 2021-03-22), p. 7399-7408
    Abstract: Excessive production of oxidative species alters the normal redox balance and leads to diseases, such as chronic inflammation and cancer. Oxidative species are short‐lived species, which makes direct, precise, and real‐time measurements difficult. Herein, we report a novel core–satellite gold nanostructure for dual, ratiometric surface‐enhanced Raman scattering (SERS) and photoacoustic (PA) imaging to enable the precise detection of inflammation/cancer‐related H 2 O 2 . The combination of H 2 O 2 ‐activated second near‐infrared (NIR‐II) PA imaging and SERS imaging enables the differentiation between the inflamed region and normal tissue with high accuracy. The mesoporous silica shell of the nanoprobe could be used to deliver drugs to the target area to precisely treat disease. Therefore, this core–satellite nanostructure can not only quantitatively and precisely monitor H 2 O 2 produced in inflammation, tumor, and osteoarthritis in rabbits in real‐time, but can also be used to track the progress of the anti‐inflammatory treatment in real‐time.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.13
    DOI: 10.1002/ange.202015451
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Dual Ratiometric SERS and Photoacoustic Core–Satellite Nanoprobe for Quantitatively Visualizing Hydrogen Peroxide in Inflammation and Cancer
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 13 ( 2021-03-22), p. 7323-7332
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 13 ( 2021-03-22), p. 7323-7332
    Abstract: Excessive production of oxidative species alters the normal redox balance and leads to diseases, such as chronic inflammation and cancer. Oxidative species are short‐lived species, which makes direct, precise, and real‐time measurements difficult. Herein, we report a novel core–satellite gold nanostructure for dual, ratiometric surface‐enhanced Raman scattering (SERS) and photoacoustic (PA) imaging to enable the precise detection of inflammation/cancer‐related H 2 O 2 . The combination of H 2 O 2 ‐activated second near‐infrared (NIR‐II) PA imaging and SERS imaging enables the differentiation between the inflamed region and normal tissue with high accuracy. The mesoporous silica shell of the nanoprobe could be used to deliver drugs to the target area to precisely treat disease. Therefore, this core–satellite nanostructure can not only quantitatively and precisely monitor H 2 O 2 produced in inflammation, tumor, and osteoarthritis in rabbits in real‐time, but can also be used to track the progress of the anti‐inflammatory treatment in real‐time.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.13
    DOI: 10.1002/anie.202015451
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 3 ( 2021-01-18), p. 1306-1312
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 3 ( 2021-01-18), p. 1306-1312
    Abstract: The design of bright NIR‐II luminescent nanomaterials that enable efficient labelling of proteins without disturbing their physiological properties in vivo is challenging. We developed an efficient strategy to synthesize bright NIR‐II gold nanoclusters (Au NCs) protected by biocompatible cyclodextrin (CD). Leveraging the ultrasmall size of Au NCs ( 〈 2 nm) and strong macrocycle‐based host–guest chemistry, the as‐synthesized CD‐Au NCs can readily label proteins/antibodies. Moreover, the labelled proteins/antibodies enable highly efficient in vivo tracking during blood circulation, without disturbing their biodistribution and tumor targeting ability, thus leading to a sensitive tumor‐targeted imaging. CD‐Au NCs are stable in the harsh biological environment and show good biocompatibility and high renal clearance efficiency. Therefore, the NIR‐II biolabels developed in this study provide a promising platform to monitor the physiological behavior of biomolecules in living organisms.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.3
    DOI: 10.1002/anie.202010870
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Ag + ‐Coupled Black Phosphorus Vesicles with Emerging NIR‐II Photoacoustic Imaging Performance for Cancer Immune‐Dynamic Therapy and Fast Wound Healing
    Wiley ; 2020
    In:  Angewandte Chemie International Edition Vol. 59, No. 49 ( 2020-12), p. 22202-22209
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 59, No. 49 ( 2020-12), p. 22202-22209
    Abstract: A silver‐ion‐coupled black phosphorus (BP) vesicle (BP Ve‐Ag + ) with a second near infrared (NIR‐II) window photoacoustic (PA) imaging capability was firstly constructed to maximize the potential of BP quantum dot (QD) in deeper bioimaging and diversified therapy. The embedded Ag + could improve the relatively large band gap of BP QD via intense charge coupling based on theoretical simulation results, subsequently leading to the enhanced optical absorption capability, accompanied with the occurrence of the strong NIR‐II PA signal. Guiding by NIR‐II PA bioimaging, the hidden Ag + could be precisely released with the disassembly of Ve during photodynamic therapy process and captured by macrophages located in lesion region for arousing synergistic cancer photodynamic/Ag + immunotherapy. BP Ve‐Ag + can contrapuntally kill pathogenic bacteria and accelerate wound healing monitored by NIR‐II PA imaging.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v59.49
    DOI: 10.1002/anie.202009609
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Highly Controlled Janus Organic‐Inorganic Nanocomposite as a Versatile Photoacoustic Platform
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 32 ( 2021-08-02), p. 17647-17653
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 32 ( 2021-08-02), p. 17647-17653
    Abstract: Controlling the structural order of nanoparticles (NPs), morphology, and composition is of paramount significance in tailoring the physical properties of nanoassembly. However, the commonly reported symmetrical nanocomposites often suffer an interference or sacrifice of the photophysical properties of the original components. To address this challenge, we developed a novel type of organic‐inorganic Janus nanocomposite (JNCP) with an asymmetric architecture, offering unique features such as the precisely controlled localization of components, combined modular optical properties, and independent stimuli. As a proof of concept, JNCPs were prepared by incorporating two photoacoustic (PA) imaging agents, namely an organic semiconducting dye and responsive gold nanoparticles (AuNP) assembly in separate compartments of JNCP. Theoretical simulation results confirmed that the formation mechanism of JNCPs arises from the entropy equilibrium in the system. The AuNP assembly generated a PA images with the variation of pH, while the semiconducting molecule served as an internal PA standard agent, leading to ratiometric PA imaging of pH. JNCP based probe holds great potential for real‐time and accurate detection of diverse biological targets in living systems.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.32
    DOI: 10.1002/anie.202105207
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
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    Online Resource
  • 7
    Online Resource
    Online Resource
    Highly Controlled Janus Organic‐Inorganic Nanocomposite as a Versatile Photoacoustic Platform
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 32 ( 2021-08-02), p. 17788-17794
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 32 ( 2021-08-02), p. 17788-17794
    Abstract: Controlling the structural order of nanoparticles (NPs), morphology, and composition is of paramount significance in tailoring the physical properties of nanoassembly. However, the commonly reported symmetrical nanocomposites often suffer an interference or sacrifice of the photophysical properties of the original components. To address this challenge, we developed a novel type of organic‐inorganic Janus nanocomposite (JNCP) with an asymmetric architecture, offering unique features such as the precisely controlled localization of components, combined modular optical properties, and independent stimuli. As a proof of concept, JNCPs were prepared by incorporating two photoacoustic (PA) imaging agents, namely an organic semiconducting dye and responsive gold nanoparticles (AuNP) assembly in separate compartments of JNCP. Theoretical simulation results confirmed that the formation mechanism of JNCPs arises from the entropy equilibrium in the system. The AuNP assembly generated a PA images with the variation of pH, while the semiconducting molecule served as an internal PA standard agent, leading to ratiometric PA imaging of pH. JNCP based probe holds great potential for real‐time and accurate detection of diverse biological targets in living systems.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.32
    DOI: 10.1002/ange.202105207
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Ag + ‐Coupled Black Phosphorus Vesicles with Emerging NIR‐II Photoacoustic Imaging Performance for Cancer Immune‐Dynamic Therapy and Fast Wound Healing
    Wiley ; 2020
    In:  Angewandte Chemie Vol. 132, No. 49 ( 2020-12), p. 22386-22393
    Details
    In: Angewandte Chemie, Wiley, Vol. 132, No. 49 ( 2020-12), p. 22386-22393
    Abstract: A silver‐ion‐coupled black phosphorus (BP) vesicle (BP Ve‐Ag + ) with a second near infrared (NIR‐II) window photoacoustic (PA) imaging capability was firstly constructed to maximize the potential of BP quantum dot (QD) in deeper bioimaging and diversified therapy. The embedded Ag + could improve the relatively large band gap of BP QD via intense charge coupling based on theoretical simulation results, subsequently leading to the enhanced optical absorption capability, accompanied with the occurrence of the strong NIR‐II PA signal. Guiding by NIR‐II PA bioimaging, the hidden Ag + could be precisely released with the disassembly of Ve during photodynamic therapy process and captured by macrophages located in lesion region for arousing synergistic cancer photodynamic/Ag + immunotherapy. BP Ve‐Ag + can contrapuntally kill pathogenic bacteria and accelerate wound healing monitored by NIR‐II PA imaging.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v132.49
    DOI: 10.1002/ange.202009609
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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