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  • Ge, Shengyou  (5)
  • 1
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-1-28)
    Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. In the tumor microenvironment, tumor-associated neutrophils (TANs) can promote tumor growth, invasion, and metastasis. The aim of our study was to explore the relationship between neutrophils infiltration and Chemerin expression in tumor cells, as well as their relationship with the clinicopathological parameters and clinical prognosis of 74 cases of OSCC. We also explored the role of the interaction between neutrophils and Chemerin in the functions of OSCC cells (Cal27, SCC9, and SCC15) in vitro . Our results showed that in OSCC, Chemerin over-expression may increase neutrophils infiltration in tumor tissues. Chemerin over-expression and neutrophils infiltration were the prognostic factors of poor clinical outcomes. Furthermore, we discovered that neutrophils promoted OSCC migration, invasion, and proliferation and EMT through Chemerin. Neutrophils activated JAK2/STAT3 signaling through Chemerin and then up-regulated its downstream signaling target genes, such as Phospho-Rb, E2F1, CyclinE1, and CyclinD1. Taken together, our results revealed that neutrophils and Chemerin are potentially involved in OSCC progression and metastasis. Neutrophils may promote the JAK2/STAT3 signaling pathway and EMT in OSCC cells through Chemerin.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  The Cleft Palate-Craniofacial Journal
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications
    Abstract: Neonatal teratoma, a common congenital malformation, rarely occurs in the head and neck region, especially not within the oral cavity. This report presents a case of neonatal giant teratoma in the oral cavity and oropharynx along with cleft palate, which caused postnatal airway obstruction and respiratory distress and required postnatal resection in a female newborn. After the delivery and routine neonatal examination, the anesthesiologist conducted orotracheal intubation to establish the airway, and tumor resection was immediately done under local anesthesia. The optimal treatment of neonatal teratoma is exclusive emergent surgery. Immediate postnatal resection is necessary to prevent airway obstruction.
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2030056-6
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  • 3
    In: International Immunopharmacology, Elsevier BV, Vol. 121 ( 2023-08), p. 110540-
    Type of Medium: Online Resource
    ISSN: 1567-5769
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2049924-3
    SSG: 15,3
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  • 4
    In: Molecules, MDPI AG, Vol. 27, No. 24 ( 2022-12-13), p. 8832-
    Abstract: The strategy of incorporating bioactive inorganic nanomaterials without side effects as osteoinductive supplements is promising for bone regeneration. In this work, a novel biomass nanofibrous scaffold synthesized by electrospinning silica (SiO2) nanoparticles into polycaprolactone/chitosan (PCL/CS) nanofibers was reported for bone tissue engineering. The nanosilica-anchored PCL/CS nanofibrous bioscaffold (PCL/CS/SiO2) exhibited an interlinked continuous fibers framework with SiO2 nanoparticles embedded in the fibers. Compact bone-derived cells (CBDCs), the stem cells derived from the bone cortex of the mouse, were seeded to the nanofibrous bioscaffolds. Scanning electron microscopy and cell counting were used to observe the cell adhesion. The Counting Kit-8 (CCK-8) assay was used. Alkaline phosphatase (ALP), Alizarin red staining, real-time Polymerase Chain Reaction and Western blot tests were performed to confirm the osteogenesis of the CBDCs on the bioscaffolds. The research results demonstrated that the mechanical property of the PCL together with the antibacterial and hydrophilic properties of the CS are conducive to promoting cell adhesion, growth, migration, proliferation and differentiation. SiO2 nanoparticles, serving as bone induction factors, effectively promote the osteoblast differentiation and bone regeneration. This novel SiO2-anchored nanofibrous bioscaffold with superior bone induction activity provides a better way for bone tissue regeneration.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 5
    In: Oral Surgery, Wiley, Vol. 15, No. 2 ( 2022-05), p. 170-177
    Abstract: This study aimed at evaluating the clinical manifestations and therapeutic options for oral and maxillofacial space infections originating from the third molar. Methods Clinical data for 60 patients with oral and maxillofacial space infections with a third molar origin who were treated between June 2016 and December 2020 in the Department of Oral and Maxillofacial Surgery of the Affiliated Hospital of Qingdao University were collected. Based on whether they were diabetic or not, patients were assigned into two groups: the diabetes mellitus (DM) group and the non‐DM group. The collected basic information included gender, age, systemic diseases, etiology and infected areas, whereas treatment information included antibiotic administration, length of hospitalisation, costs, bacteria and sensitivity tests as well as associated complications. Results Of the 60 patients, 36 were males while 24 were females with an age range of 21–51 years. A total of 32 patients exhibited third molar pericoronitis, whereas 26 patients had deep neck space or chest cavity infections. Compared to the non‐DM group, the length of hospital stay was relatively longer while antibiotic administration was higher in the DM group. The conformance rate of empirical antibiotic use and drug sensitivity tests was 64.9% (37/57). Conclusion DM is a risk factor for oral and maxillofacial space infections. Space infections with third molar origins are associated with serious complications. Based on patient's conditions, treatment plans should be comprehensively evaluated and personalised treatment plans formulated. Antibiotic administration by clinicians is not standardised; therefore, it is important to make adjustments depending on subsequent bacterial culture results.
    Type of Medium: Online Resource
    ISSN: 1752-2471 , 1752-248X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2423337-7
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