GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • SAGE Publications  (4)
  • Gao, Yuan  (4)
Material
Publisher
  • SAGE Publications  (4)
Language
Years
  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  International Journal of Damage Mechanics Vol. 26, No. 5 ( 2017-07), p. 771-797
    In: International Journal of Damage Mechanics, SAGE Publications, Vol. 26, No. 5 ( 2017-07), p. 771-797
    Abstract: This article focuses on the modeling of shrinkage stress and evaluation of shrinkage induced cracking in early-age concrete. In the modeling, an integrative model for autogenous and drying shrinkage predictions of concrete at early-age is introduced first. Second, a model taking both cement hydration and moisture diffusion into account is used to calculate the distribution of internal humidity in concrete. Using above two models, the distribution of shrinkage stress in concrete ring and column at early-age from concrete cast are calculated. Meanwhile, the ring test is utilized to identify the time of shrinkage cracking of three kinds of concretes with compressive strength at 28 days around 30, 50, and 80 MPa. Based on model and ring test results, the shrinkage induced cracking tendency of concrete columns made of the three kinds of concretes is evaluated individually. The model results show that before drying, a uniform shrinkage strain along radial direction of a concrete column or ring is expected. After surface drying, shrinkage gradient along the radial direction is significant and the maximum and minimum shrinkage occur at the outer surface and the center of column or interior surface of the ring, respectively. The distribution of shrinkage stress along the radial direction of the ring or column is nonlinear and the nonlinearity is strong close to the drying surface. Due to the difference on restraint condition, lower shrinkage induced cracking tendency is expected in concrete column than that of steel restraint concrete ring, even both of them having the exact same outer diameter.
    Type of Medium: Online Resource
    ISSN: 1056-7895 , 1530-7921
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2052623-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Journal of Investigative Medicine Vol. 70, No. 4 ( 2022-04), p. 907-913
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 70, No. 4 ( 2022-04), p. 907-913
    Abstract: Calcific aortic valve disease (CAVD) is an active pathological process mediated by abnormal activation and transdifferentiation of valvular interstitial cells (VICs). The present study aims to investigate the function and underlying mechanism of the basic fibroblast growth factor (BFGF) on osteogenic differentiation of VICs. Porcine VICs cultured with osteogenic induction medium are supplemented with or without BFGF. Morphology of VICs is identified by fluorescein isothiocyanate-labeled phalloidin, the cell viability is assessed by the cell counting kit-8 method, and protein and mRNA expression level of osteogenic differentiation markers, including Runx2, osteopontin, and Sp7, are verified by western blot analysis and quantitative real-time PCR, respectively. RNA sequencing is used to identify changes in gene profiles. Alizarin Red S staining is used to measure calcium deposition. The results demonstrate that the content of calcium deposition and the expression level of osteogenic markers are downregulated by supplementing BFGF. Notch1 signaling pathway is extracted as a candidate target after bioinformatics analysis by RNA sequencing. The transfection of si-Notch1 abolishes the calcification inhibitory effect of BFGF. Taken together, our findings shed the light on the mechanism and potential therapeutics of BFGF for CAVD.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  The International Journal of Biological Markers Vol. 37, No. 3 ( 2022-09), p. 296-305
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 37, No. 3 ( 2022-09), p. 296-305
    Abstract: A whole-exome or targeted cancer genes panel by next-generation sequencing has been used widely in assisting individualized treatment decisions. Currently, multiple algorithms are developed to estimate DNA copy numbers based on sequencing data, which makes a comprehensive global glance at chromosomal integrity possible. We aim to classify gastric cancers based on chromosomal integrity to guide personalized therapy. Methods We investigated copy number variations (CNV) across the entire genome of 124 gastric carcinomas via exome or targeted sequencing. Chromosomal integrity was classified as chromosomal stability (CS), chromosomal instability (CIN) and intermediate state (CIN/CS) based on CNV results. Chromosomal integrity was correlated to molecular features and clinical characteristics. Results According the states of chromosomal integrity, gastric carcinomas can be stratified into two cohorts: CS and CIN. Our results showed a significant relationship between CIN status and TP53 mutation, but not RB1, phosphatase and tensin homolog (PTEN), or other reported DNA damage repair genes. The mutation frequency of the TP53 gene had great relevance. Our study initially revealed clinical significance of chromosomal integrity that CIN patients were prone to HER2-positive and mucinous adenocarcinoma, while CS patients were a diffuse subtype and poorly differentiated but had longer overall survival. Conclusions We classified gastric carcinomas into two states of chromosomal integrity with clinical implications. The dichotomy is applicable to clinical transformation. We proposed that classifying gastric cancers based on chromosomal integrity would enable us to achieve personalized therapy for patients and may be beneficial to patient stratification in future clinical trials.
    Type of Medium: Online Resource
    ISSN: 0393-6155 , 1724-6008
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1475778-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  Journal of Biomaterials Applications Vol. 35, No. 10 ( 2021-05), p. 1304-1314
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 35, No. 10 ( 2021-05), p. 1304-1314
    Abstract: Spinal fusion cages are commonly used to treat spinal diseases caused by degenerative changes, deformities, and trauma. At present, most of the main clinical spinal fusion cage products are non-degradable and still cause some undesirable side effects, such as the stress shielding phenomenon, interference with postoperative medical imaging, and obvious foreign body sensation in patients. Degradable spinal fusion cages have promising potential with extensive perspectives. The purpose of this study was to fabricate a degradable spinal fusion cage from both polycaprolactone (PCL) and high-proportion beta-tricalcium phosphate (β-TCP), using the highly personalised, accurate, and rapid fused deposition modelling 3 D printing technology. PCL and β-TCP were mixed in three different ratios (60:40, 55:45, and 50:50). Both in vitro degradation and cell experiments proved that all cages with the different PCL:β-TCP ratios met the mechanical properties of human cancellous bone while maintaining their structural integrity. The biological activity of the cages improved with higher amounts of the β-TCP content. This study also showed that a spinal fusion cage with high β-TCP content and suitable mechanical properties can be manufactured using extruding rods and appropriate models, providing a new solution for the design of degradable spinal fusion cages.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2072559-0
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...