In:
Behavioural Neurology, Hindawi Limited, Vol. 2020 ( 2020-01-02), p. 1-11
Abstract:
As one of the most important therapies in complementary and alternative medicine, acupuncture has been used in the treatment of Alzheimer’s disease (AD). Acupuncture of “olfactory three-needle” manipulation can improve the cognitive ability of AD patients. However, the mechanism of “olfactory three-needle” in AD remains largely unknown. Here, we identified that the “olfactory three-needle” therapy and eugenol olfactory stimulation both reduced the deposition of β -amyloid (A β ) protein and increased the expression of synaptophysin (SYP), but only the “olfactory three-needle” enhanced the spatial learning and memory ability of SAMP8. Remarkably, the “olfactory three-needle” inhibited the phosphorylation of p38MAPK and the excessive activation of microglia (MG) in the hippocampus. Our study demonstrates that the “olfactory three-needle” enhances spatial learning and memory ability by inhibiting the phosphorylation of p38MAPK and the excessive activation of MG to reduce the neuroinflammatory response and neurotoxicity of A β and promote synaptic regeneration, but it was not completely consistent with the stimulation of the olfactory system.
Type of Medium:
Online Resource
ISSN:
0953-4180
,
1875-8584
DOI:
10.1155/2020/2893289
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2020
detail.hit.zdb_id:
2035544-0
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