In:
The Journal of Physiology, Wiley, Vol. 595, No. 18 ( 2017-09-15), p. 6091-6120
Abstract:
Glomus cells in the carotid body (CB) and chromaffin cells in the adrenal medulla (AM) are essential for reflex cardiorespiratory adaptation to hypoxia. However, the mechanisms whereby these cells detect changes in O 2 tension are poorly understood. The metabolic properties of acute O 2 ‐sensing cells have been investigated by comparing the transcriptomes of CB and AM cells, which are O 2 ‐sensitive, with superior cervical ganglion neurons, which are practically O 2 ‐insensitive. In O 2 ‐sensitive cells, we found a characteristic prolyl hydroxylase 3 down‐regulation and hypoxia inducible factor 2α up‐regulation, as well as overexpression of genes coding for three atypical mitochondrial electron transport subunits and pyruvate carboxylase, an enzyme that replenishes tricarboxylic acid cycle intermediates. In agreement with this observation, the inhibition of succinate dehydrogenase impairs CB acute O 2 sensing. The responsiveness of peripheral chemoreceptor cells to acute hypoxia depends on a ‘signature metabolic profile’.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
DOI:
10.1113/tjp.2017.595.issue-18
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1475290-6
SSG:
12
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