In:
Chemistry – A European Journal, Wiley, Vol. 27, No. 23 ( 2021-04-21), p. 6917-6922
Abstract:
Liposomes are versatile three‐dimensional, biomaterial‐based frameworks that can spatially enclose a variety of organic and inorganic biomaterials for advanced targeted‐delivery applications. Implementation of external‐stimuli‐controlled release of their cargo will significantly augment their wide application for liposomal drug delivery. This paper presents the synthesis of a carbohydrate‐derived lipid, capable of changing its conformation depending on the presence of Zn 2+ : an active state in the presence of Zn 2+ ions and back to an inactive state in the absence of Zn 2+ or when exposed to Na 2 EDTA, a metal chelator with high affinity for Zn 2+ ions. This is the first report of a lipid triggered by the presence of a metal chelator. Total internal reflection fluorescence microscopy and a single‐liposome study showed that it indeed was possible for the lipid to be incorporated into the bilayer of stable liposomes that remained leakage‐free for the fluorescent cargo of the liposomes. On addition of EDTA to the liposomes, their fluorescent cargo could be released as a result of the membrane‐incorporated lipids undergoing a conformational change.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.202005332
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1478547-X
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