In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2019, No. 6 ( 2019-02-14), p. 856-864
Abstract:
The oxaliplatin derivative ( SP ‐4‐3)‐oxalato[(1 R ,2 R ,4 R /1 S ,2 S ,4 S )‐(4‐trifluoromethyl‐cyclohexane‐1,2‐diamine)]platinum(II) hosting a trifluoromethyl group at position 4 of the cyclohexane ring is presented. The ligand was synthesized as an 1 R ,2 R ,4 R /1 S ,2 S ,4 S racemic mixture starting from 4‐trifluoromethyl‐cyclohexanol over five steps and coordinated to platinum to yield first the dichlorido and subsequently the oxalato complex. This novel compound and its analogue featuring a ( 13 C 2 )oxalate ligand were characterized by multinuclear ( 1 H, 13 C, 15 N, 19 F, 195 Pt) one‐ and two‐dimensional NMR spectroscopy. Ligand exchange and adduct formation reactions with DMSO, NaCl, CaCl 2 , l ‐methionine, and 5′‐GMP were investigated via time‐dependent measurements by 19 F and 13 C NMR spectroscopy. The cytotoxicity of the title complex was investigated in three human cancer cell lines; the IC 50 values were found in the low micromolar range, attesting moderate to high antiproliferative activity, depending on the cell line.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2019.6
DOI:
10.1002/ejic.201801370
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1475009-0
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