In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-28), p. e0245995-
Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) induce small intestinal damage. It has been reported that rebamipide, a mucoprotective drug, exerts a protective effect against NSAID-induced small intestinal damage; however, the underlying mechanism remains unknown. In this study, we investigated the significance of the small intestinal microbiota in the protective effect of rebamipide against indomethacin-induced small intestinal damage in mice. A comprehensive analysis of the 16S rRNA gene sequencing revealed an alteration in the composition of the small intestinal microbiota at the species level, modulated by the administration of rebamipide and omeprazole. The transplantation of the small intestinal microbiota of the mice treated with rebamipide suppressed the indomethacin-induced small intestinal damage. Omeprazole, a proton pump inhibitor, exacerbated the indomethacin-induced small intestinal damage, which was accompanied by the alteration of the small intestinal microbiota. We found that the transplantation of the small intestinal microbiota of the rebamipide-treated mice ameliorated indomethacin-induced small intestinal damage and the omeprazole-induced exacerbation of the damage. These results suggest that rebamipide exerts a protective effect against NSAID-induced small intestinal damage via the modulation of the small intestinal microbiota, and that its ameliorating effect extends also to the exacerbation of NSAID-induced small intestinal damage by proton pump inhibitors.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245995
DOI:
10.1371/journal.pone.0245995.g001
DOI:
10.1371/journal.pone.0245995.g002
DOI:
10.1371/journal.pone.0245995.g003
DOI:
10.1371/journal.pone.0245995.g004
DOI:
10.1371/journal.pone.0245995.g005
DOI:
10.1371/journal.pone.0245995.g006
DOI:
10.1371/journal.pone.0245995.t001
DOI:
10.1371/journal.pone.0245995.t002
DOI:
10.1371/journal.pone.0245995.t003
DOI:
10.1371/journal.pone.0245995.s001
DOI:
10.1371/journal.pone.0245995.s002
DOI:
10.1371/journal.pone.0245995.s003
DOI:
10.1371/journal.pone.0245995.s004
DOI:
10.1371/journal.pone.0245995.s005
DOI:
10.1371/journal.pone.0245995.s006
DOI:
10.1371/journal.pone.0245995.s007
DOI:
10.1371/journal.pone.0245995.r001
DOI:
10.1371/journal.pone.0245995.r002
DOI:
10.1371/journal.pone.0245995.r003
DOI:
10.1371/journal.pone.0245995.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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